Excellent Cosmetic Ingredient NOAEL Data

Triethoxycaprylylsilane

INCI: TRIETHOXYCAPRYLYLSILANE

CAS Number
2943-75-1
Function
Binder, Surface Modifier, Skin Conditioning Agent (used to coat pigments and UV filters)
Safety Rating
EXCELLENT

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes Permitted; CIR Expert Panel concluded safe as used in cosmetics

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
negligible
Sensitization
none

Calculate MoS for your specific formulation with the MoS Calculator.

Toxicological Studies

4 study endpoints found for Triethoxycaprylylsilane. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint Value Route Species Study Type Source
NOAEL ca.250 mg/kg bw/day oral rat oral REACH
NOAEL 10000 other oral rat oral REACH
NOAEL >=10000 ppm oral rat oral REACH
NOAEL 300 mg/kg bw/day oral rat oral REACH

Expert Verdict

Highly reactive Si-O bond hydrolyzes in moisture โ€” handle appropriately in raw form; safe once reacted/coated onto substrates

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Concern Level: None

Frequently Asked Questions

Is Triethoxycaprylylsilane safe in cosmetics?

Highly reactive Si-O bond hydrolyzes in moisture โ€” handle appropriately in raw form; safe once reacted/coated onto substrates The EU classifies Triethoxycaprylylsilane as "permitted". Safety rating: EXCELLENT. 4 toxicological study endpoint(s) are available in our database.

Is Triethoxycaprylylsilane allowed in the EU?

Triethoxycaprylylsilane EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Triethoxycaprylylsilane do in cosmetics?

Triethoxycaprylylsilane functions as: Binder, Surface Modifier, Skin Conditioning Agent (used to coat pigments and UV filters). It is classified as a cosmetic ingredient in our database. CAS number: 2943-75-1.

What is the Margin of Safety for Triethoxycaprylylsilane?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

What is the NOAEL for Triethoxycaprylylsilane?

The NOAEL (No Observed Adverse Effect Level) for Triethoxycaprylylsilane is ca.250 mg/kg bw/day based on a oral study via oral route in rat. A total of 4 study endpoints are available. Source: REACH.

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