Is METHYLENEDIOXYPHENYL METHYLPROPANAL safe in cosmetics?
METHYLENEDIOXYPHENYL METHYLPROPANAL has a safety rating of "GOOD" in our database. EU status: permitted. 3 toxicological study endpoint(s) are available in our database.
METHYLENEDIOXYPHENYL METHYLPROPANAL
Also known as: 1,3-Benzodioxole-5-propanal, alpha-methyl-, 1,3-Benzodioxole-5-propanal, .alpha.-methyl-, alpha-Methyl-1,3-benzodioxole-5-propionaldehyde, Hydrocinnamaldehyde, alpha-methyl-3,4-(methylenedioxy)- (8CI), EINECS 214-881-6 (+5 more)
METHYLENEDIOXYPHENYL METHYLPROPANAL (CAS 1205-17-0) is a cosmetic cosmetic ingredient functioning as Perfuming. Reported NOAEL =50 mg/kg bw/day in Rat (ToxValDB_ECHA_IUCLID); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 1205-17-0 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
METHYLENEDIOXYPHENYL METHYLPROPANAL is classified GHS CMR hazard (H317, H411, H361, H401) in the chemicals database but is allowed in EU cosmetics.
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
Perfuming
Safety Rating
GOOD
Chemistry & Identifiers
IUPAC Name
3-(1,3-benzodioxol-5-yl)-2-methylpropanal
InChIKey
BOPPSUHPZARXTH-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
Not specifically regulated
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Toxicological Studies
3 study endpoints found for METHYLENEDIOXYPHENYL METHYLPROPANAL. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =50 mg/kg bw/day | dermal | Rat | acute | ToxValDB_ECHA_IUCLID |
| NOAEL | =125 mg/kg bw/day | oral | Rat | reproduction developmental | ToxValDB_ECHA_IUCLID |
| NOAEL | =250 mg/kg bw/day | oral | Rat | developmental | ToxValDB_ECHA_IUCLID |
Sensitization AOP Dashboard
Adverse Outcome Pathway data across 5 assays (DPRA, KeratinoSens, hCLAT, LLNA, NESIL) aggregated from public sources.
DPRA Cys %
44.85%
DPRA Lys %
3.74%
KeratinoSens IC50
710.359 µM
hCLAT CV75
154 µg/mL
LLNA EC3
16.4%
NESIL
4100 µg/cm²
LLNA: Weak (1B)
GHS: 1B
Source: LLNA: Kern et al. (2010); DPRA: Hoffmann et al., 2018; KS: Natsch et al. 2015 [DOI:10.1093/toxsci/kfu229]; hCLAT: No reference provided in NICEATM database
HRIPT Human Patch Test Studies
2 human repeat insult patch tests aggregated from dermatological literature.
| Test Type | N | Sensitized | Dose µg/cm² | NESIL µg/cm² | Potency |
|---|---|---|---|---|---|
| HRIPT | 109 | 0 | 11810 | 11810 | non-sensitizer |
| HRIPT | 115 | 0 | 4015 | 4015 | non-sensitizer |
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
100 - 1,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Hazard classification: Restricted (Annex XVII)
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (1)
Endocrine Disruptors
Potential endocrine disrupting compound
Source: NORMAN Suspect List Exchange
Regulatory (2)
JECFA Number
2212
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
3-(3,4-METHYLENEDIOXYPHENYL)-2- METHYLPROPANAL | 2016 | EVALUATION IS NOT COMPLETED | Additional data required to complete evaluation | ">TRS 1000-JECFA 82/111 | FAS 73 JECFA 82/403
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Flavouring and nutrient
Fragrance
Regulatory List Membership (2)
IFRA Fragrance Transparency List
FDA Substances Added to Food (EAFUS)
Expert Verdict
Expert safety assessment and concern-level summary for METHYLENEDIOXYPHENYL METHYLPROPANAL.
Regulatory Flags
cosing-sourced
eu-permitted
fragrance
needs-enrichment
ifra_fragrance
fda_food_additive
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to METHYLENEDIOXYPHENYL METHYLPROPANAL by CAS number or substance name.
Studies
3
Lowest NOAEL
50 mg/kg bw/day
Highest NOAEL
250 mg/kg bw/day
ToxValDB_ECHA_IUCLID
Known Synonyms
1,3-Benzodioxole-5-propanal, alpha-methyl-
1,3-Benzodioxole-5-propanal, .alpha.-methyl-
alpha-Methyl-1,3-benzodioxole-5-propionaldehyde
Hydrocinnamaldehyde, alpha-methyl-3,4-(methylenedioxy)- (8CI)
EINECS 214-881-6
a-Methyl-1,3-benzodioxole-5-propionaldehyde
NSC 22282
UNII-L65EG8H6PA
Ocean propanal
alpha-Methyl-3,4-methylene-dioxyhydrocinnamic aldehyde
Chemical Function
Fragrance
Regulatory Lists
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
IFRA Transparency
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL3183457
Frequently Asked Questions
Is METHYLENEDIOXYPHENYL METHYLPROPANAL allowed in the EU?
METHYLENEDIOXYPHENYL METHYLPROPANAL EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does METHYLENEDIOXYPHENYL METHYLPROPANAL do in cosmetics?
METHYLENEDIOXYPHENYL METHYLPROPANAL functions as: Perfuming. It is classified as a cosmetic ingredient in our database. CAS number: 1205-17-0.
What is the NOAEL for METHYLENEDIOXYPHENYL METHYLPROPANAL?
The NOAEL (No Observed Adverse Effect Level) for METHYLENEDIOXYPHENYL METHYLPROPANAL is =50 mg/kg bw/day based on a acute study via dermal route in Rat. A total of 3 study endpoints are available. Source: ToxValDB_ECHA_IUCLID.
Is METHYLENEDIOXYPHENYL METHYLPROPANAL used outside cosmetics?
METHYLENEDIOXYPHENYL METHYLPROPANAL also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does METHYLENEDIOXYPHENYL METHYLPROPANAL have different safety status in cosmetics vs industrial chemicals?
METHYLENEDIOXYPHENYL METHYLPROPANAL is classified GHS CMR hazard (H317, H411, H361, H401) in the chemicals database but is allowed in EU cosmetics.
Compliance Tools
Check METHYLENEDIOXYPHENYL METHYLPROPANAL compliance across multiple jurisdictions:
Ingredient Decoder
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Substance Compliance
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MoS Calculator
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Heavy Metal Limits
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