Good Cosmetic Ingredient NOAEL Data GHS Classified

MIBK

CAS Number
108-10-1
Function
Denaturant, Perfuming, Solvent
Safety Rating
GOOD

Regulatory Status

🇪🇺 EU Status Permitted
🇺🇸 US Status restricted
US Notes CIR: SQ - IJT 23(Suppl. 1):29-57, 2004

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Toxicological Studies

8 study endpoints found for MIBK. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint Value Route Species Study Type Source
NOAEL 681 mg/kg bw/day oral rat Special Toxicology Study COSMOS_DB
NOAEL 1362 mg/kg bw/day oral rat Special Toxicology Study COSMOS_DB
NOAEL 681 mg/kg bw/day oral rat Special Toxicology Study COSMOS_DB
NOAEL 681 mg/kg bw/day oral rat Special Toxicology Study COSMOS_DB
NOAEL 681 mg/kg bw/day oral rat Special Toxicology Study COSMOS_DB
dose_tested 681 mg/kg bw/day oral rat Special Toxicology Study COSMOS_DB
dose_tested 1362 mg/kg bw/day oral rat Special Toxicology Study COSMOS_DB
NOEL 50 mg/kg bw/day oral rat oral REACH

GHS Hazard Classification

Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.

Short-term Exposure Effects
The substance and the vapour are irritating to the eyes, skin and respiratory tract. If this liquid is swallowed, aspiration into the lungs may result in chemical pneumonitis. The substance may cause effects on the central nervous system at high concentrations. This may result in narcosis.
Long-term Exposure Effects
Repeated or prolonged contact with skin may cause dermatitis.
Routes of Exposure
The substance can be absorbed into the body by inhalation of its vapour and by ingestion.

Expert Verdict

MIBK is listed in the EU CosIng database with functions: Denaturant, Perfuming, Solvent It is permitted in the EU without specific restrictions.

⚠️
Concern Level: Low

Regulatory Flags

cosing-sourced eu-permitted fragrance needs-enrichment prop65 ifra_fragrance fda_food_additive

Frequently Asked Questions

Is MIBK safe in cosmetics?

MIBK is listed in the EU CosIng database with functions: Denaturant, Perfuming, Solvent It is permitted in the EU without specific restrictions. The EU classifies MIBK as "Permitted". Safety rating: GOOD. 8 toxicological study endpoint(s) are available in our database.

Is MIBK allowed in the EU?

MIBK EU regulatory status: Permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does MIBK do in cosmetics?

MIBK functions as: Denaturant, Perfuming, Solvent. It is classified as a cosmetic ingredient in our database. CAS number: 108-10-1.

What is the NOAEL for MIBK?

The NOAEL (No Observed Adverse Effect Level) for MIBK is 681 mg/kg bw/day based on a Special Toxicology Study study via oral route in rat. A total of 8 study endpoints are available. Source: COSMOS_DB.

Compliance Tools

Check MIBK compliance across multiple jurisdictions:

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Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
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Substance Compliance
Check compliance across 55 jurisdictions
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
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Heavy Metal Limits
Compare limits across jurisdictions

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