Moderate Cosmetic Ingredient NOAEL Data GHS Classified

MORPHOLINE

CAS Number
110-91-8
Function
Buffering
Safety Rating
MODERATE

Regulatory Status

🇪🇺 EU Status Restricted
EU Max Conc. II/344
🇺🇸 US Status prohibited
US Notes Not specifically listed on FDA's prohibited cosmetics list, but subject to general safety requirements under FD\&C Act; FDA has expressed concern about nitrosamine-forming amines

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Toxicological Studies

10 study endpoints found for MORPHOLINE. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint Value Route Species Study Type Source
NOAEL 6316 mg/kg bw/day oral mouse Subchronic COSMOS_DB
NOAEL 50 mg/kg bw/day oral rat Carcinogenicity COSMOS_DB
NOAEL 120 mg/kg bw/day oral hamster Carcinogenicity COSMOS_DB
NOAEL 160 mg/kg bw/day oral rat Short Term Toxicity COSMOS_DB
NOAEL 90 mg/kg bw/day oral guinea pig Short Term Toxicity COSMOS_DB
dose_tested 6316 mg/kg bw/day oral mouse Subchronic COSMOS_DB
dose_tested 50 mg/kg bw/day oral rat Carcinogenicity COSMOS_DB
dose_tested 120 mg/kg bw/day oral hamster Carcinogenicity COSMOS_DB
NOAEL 200 mg/kg bw/day oral rat oral REACH
NOAEL 200 mg/kg bw/day oral - oral REACH

GHS Hazard Classification

Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.

Short-term Exposure Effects
The substance is corrosive to the eyes, skin and respiratory tract. Corrosive on ingestion. Inhalation of the vapour may cause lung oedema. See Notes.
Long-term Exposure Effects
The substance may have effects on the liver and kidneys.
Routes of Exposure
The substance can be absorbed into the body by inhalation, through the skin and by ingestion.

Expert Verdict

MORPHOLINE is listed in the EU CosIng database with functions: Buffering It is restricted under EU Cosmetics Regulation. Restriction: II/344.

⚠️
Concern Level: Medium

Regulatory Flags

cosing-sourced eu-restricted needs-enrichment eu_banned_cosmetics fda_food_additive eu_cosing_listed

Frequently Asked Questions

Is MORPHOLINE safe in cosmetics?

MORPHOLINE is listed in the EU CosIng database with functions: Buffering It is restricted under EU Cosmetics Regulation. Restriction: II/344. The EU classifies MORPHOLINE as "Restricted". Safety rating: MODERATE. 10 toxicological study endpoint(s) are available in our database.

Is MORPHOLINE allowed in the EU?

MORPHOLINE EU regulatory status: Restricted. Maximum allowed concentration: II/344. This is based on EU Regulation 1223/2009 and its amendments.

What does MORPHOLINE do in cosmetics?

MORPHOLINE functions as: Buffering. It is classified as a cosmetic ingredient in our database. CAS number: 110-91-8.

What is the NOAEL for MORPHOLINE?

The NOAEL (No Observed Adverse Effect Level) for MORPHOLINE is 6316 mg/kg bw/day based on a Subchronic study via oral route in mouse. A total of 10 study endpoints are available. Source: COSMOS_DB.

Compliance Tools

Check MORPHOLINE compliance across multiple jurisdictions:

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Ingredient Decoder
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82 Allergen Checker
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Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
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Heavy Metal Limits
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Good
AMINOETHYL PROPANEDIOL
Good
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