Is MORPHOLINE safe in cosmetics?
MORPHOLINE has a safety rating of "MODERATE" in our database. EU status: restricted. US status: prohibited.
MORPHOLINE
Also known as: 4-27-00-00015, BRN 0102549, Caswell No. 584, EINECS 203-815-1, EPA Pesticide Chemical Code 054701 (+2 more)
MORPHOLINE (CAS 110-91-8) is a cosmetic cosmetic ingredient functioning as Buffering. NOAEL 50 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: restricted, max II/344. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety, pharmaceutical, and food safety data.
View industrial chemical safety profile for CAS 110-91-8 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
MORPHOLINE is classified GHS Danger (H226, H290, H302, H312, H332, H314, H318, H411) in the chemicals database but is restricted in EU cosmetics at max II/344.
Source: Cosmetics: ingredients.eu_status/eu_max; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
Buffering
Safety Rating
MODERATE
Chemistry & Identifiers
IUPAC Name
morpholine
InChIKey
YNAVUWVOSKDBBP-UHFFFAOYSA-N
Regulatory Status
EU EU Status
restricted
EU Max Conc.
II/344
US US Status
prohibited
US Notes
Not specifically listed on FDA's prohibited cosmetics list, but subject to general safety requirements under FD\&C Act; FDA has expressed concern about nitrosamine-forming amines
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
GHS Hazard Classification
Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.
Short-term Exposure Effects
The substance is corrosive to the eyes, skin and respiratory tract. Corrosive on ingestion. Inhalation of the vapour may cause lung oedema. See Notes.
Long-term Exposure Effects
The substance may have effects on the liver and kidneys.
Routes of Exposure
The substance can be absorbed into the body by inhalation, through the skin and by ingestion.
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for MORPHOLINE across SCCS product categories, with measured dermal absorption where available.
IARC Carcinogenicity
International Agency for Research on Cancer (WHO) monograph evaluation.
IARC Group
3
Volume
47, 71
Evaluation Year
1998
EU CLP Annex VI Harmonized Classification
Legally binding harmonized classification per Regulation (EC) No 1272/2008 (CLP) Annex VI.
Signal Word
Danger
Pictograms
FlammableHarmful / IrritantCorrosive
Hazard Class and Category
Flam. Liq. 3; Acute Tox. 4 *; Acute Tox. 4 *; Acute Tox. 4 *; Skin Corr. 1B
Hazard Statements
- H226 Flammable liquid and vapour
- H332 Harmful if inhaled
- H312 Harmful in contact with skin
- H302 Harmful if swallowed
- H314 Causes severe skin burns and eye damage
Inserted via ATP: CLP00
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
1,000 - 10,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Hazard classification: Restricted (Annex XVII)
EU CosIng Annex Listing
European Commission CosIng database Annex references per Regulation (EC) No 1223/2009.
Annex II — Prohibited
Ref: 344
(EC) 2009/1223
Expanded Jurisdictional Detail
Additional regulatory detail beyond the 7-jurisdiction summary: Saudi SFDA, Korea MFDS, ASEAN ACD, Japan/Korea, Brazil/India, and cross-jurisdictional restriction entries.
SA Saudi SFDA (II - Prohibited)
ASEAN Cosmetic Directive (II)
Ref: 344
BRIN Brazil/India Cosmetics
India: Prohibited (GNRAS)
Additional Jurisdictional Restrictions (2)
| Jurisdiction | Status | Max % | Product Type |
|---|---|---|---|
| CA | banned | - | - |
| KR | prohibited | - | - |
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (4)
Carcinogen Classification
Morpholine | Group 3: Not classifiable as to its carcinogenicity to humans | Volume 47: (1989) Some Organic Solvents, Resin Monomers and Related Compounds, Pigments and Occupational Exposures in Paint Manufacture and Painting | Volume 71: (1999) Re-evaluation of Some Organic Chemicals, Hydrazine and Hydrogen Peroxide (Part 1, Part 2, Part 3)
Source: International Agency for Research on Cancer (IARC)
Evidence for Carcinogenicity
Evaluation: No epidemiological data relevant to the carcinogenicity of morpholine were available. There is inadequate evidence in experimental animals for the carcinogenicity of morpholine. Overall evaluation: Morpholine is not classifiable as to its carcinogenicity to humans (Group 3). | A4; Not classifiable as a human carcinogen.
Source: Hazardous Substances Data Bank (HSDB)
ICSC Safety Card
0302
Source: ILO-WHO International Chemical Safety Cards (ICSCs)
Skin Eye Respiratory Irritation
...Concentration of 1200 ppm irritates nose in 1 min and produces cough reflex in 1-5 min. | May cause irritation of the eyes, nose, throat, lungs and skin.
Source: Hazardous Substances Data Bank (HSDB)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Chelating agent
Processing aids not otherwise specified
Solvent
pH regulating agent
Regulatory List Membership (3)
EU Banned in Cosmetics
FDA Substances Added to Food (EAFUS)
EU CosIng Cosmetics Ingredient Database
Expert Verdict
Expert safety assessment and concern-level summary for MORPHOLINE.
Regulatory Flags
cosing-sourced
eu-restricted
needs-enrichment
eu_banned_cosmetics
fda_food_additive
eu_cosing_listed
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to MORPHOLINE by CAS number or substance name.
Studies
24
Lowest NOAEL
60 mg/kg bw/day
Highest NOAEL
750 mg/kg bw/day
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip
Known Synonyms
4-27-00-00015
BRN 0102549
Caswell No. 584
EINECS 203-815-1
EPA Pesticide Chemical Code 054701
Tetrahydro-1,4-isoxazine
UNII-8B2ZCK305O
Chemical Function
pH regulating agent
Solvent
Regulatory Lists
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
inert_ingredient; non_food_use; Pesticides
active_ingredient; Europe; Pesticides
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
Canada; pharmaceutical
banned; Europe; Personal care
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical and food safety data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
MORPHOLINE
ChEMBL ID
CHEMBL276518
SOURCE
EFSA / FDA GRAS
food_additives
Food Safety Data
Same-CAS food additive or FDA GRAS records from the core public database.
Food Name
MORPHOLINE
Food Category
food_additive
Frequently Asked Questions
Is MORPHOLINE allowed in the EU?
MORPHOLINE EU regulatory status: restricted. Maximum allowed concentration: II/344. This is based on EU Regulation 1223/2009 and its amendments.
What does MORPHOLINE do in cosmetics?
MORPHOLINE functions as: Buffering. It is classified as a cosmetic ingredient in our database. CAS number: 110-91-8.
Is MORPHOLINE used outside cosmetics?
MORPHOLINE also appears in industrial chemical safety, pharmaceutical, and food safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does MORPHOLINE have different safety status in cosmetics vs industrial chemicals?
MORPHOLINE is classified GHS Danger (H226, H290, H302, H312, H332, H314, H318, H411) in the chemicals database but is restricted in EU cosmetics at max II/344.
Compliance Tools
Check MORPHOLINE compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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