Is Naringin safe in cosmetics?
Naringin has a safety rating of "EXCELLENT" in our database. EU status: permitted. US status: permitted.
EXCELLENT
Cosmetic Ingredient
Naringin
Also known as: 4H-1-Benzopyran-4-one, 7-((2-O-(6-deoxy-alpha-L-mannopyranosyl)-beta-D-glucopyranosyl)oxy)-2,3-dihydro-5-hydroxy-2-(4-hydroxyphenyl)-, (2S)-, 4H-1-Benzopyran-4-one, 7-[[2-O-(6-deoxy-.alpha.-L-mannopyranosyl)-.beta.-D-glucopyranosyl]oxy]-2,3-dihydro-5-hydroxy-2-(4-hydroxyphenyl)-, (2S)-, EINECS 233-566-4, Naringenin-7-beta-neohesperidoside, 5-Hydroxy-2-(4-hydroxyphenyl)-7-(2-O-alpha-L-rhamnopyranosyl-beta-D-glucopyranosyloxy)-4-chromanon (+3 more)
INCI: NARINGIN
Naringin (CAS 10236-47-2) is a cosmetic cosmetic ingredient functioning as Skin protecting, Antioxidant, Skin brightening, UV absorbing. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety, pharmaceutical, and food safety data.
View industrial chemical safety profile for CAS 10236-47-2 →
Function
Skin protecting, Antioxidant, Skin brightening, UV absorbing
Editorial assessment
EXCELLENT
Preliminary editorial note — not a computed safety verdict.
Chemistry & Identifiers
IUPAC Name
(2S)-7-[(2S,3R,4S,5S,6R)-4,5-dihydroxy-6-(hydroxymethyl)-3-[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxyoxan-2-yl]oxy-5-hydroxy-2-(4-hydroxyphenyl)-2,3-dihydrochromen-4-one
InChIKey
DFPMSGMNTNDNHN-ZPHOTFPESA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
No FDA cosmetic restrictions; grapefruit-derived flavanone glycoside; GRAS status for food use; no phototoxicity risk as it lacks furocoumarin structure
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Naringin.
Calculate MoS for your specific formulation with the MoS Calculator.
EPA ToxValDB — Toxicity Values
6 toxicity values from EPA ToxValDB (aggregated from CCTE, HPV, ToxRefDB, IRIS, and other regulatory dossiers).
| Endpoint | Value | Species | Route | Duration | Source |
|---|---|---|---|---|---|
| NOEL | =100 mg/kg-day | Rat | oral | short-term | ECOTOX |
| LD50 | >2000 mg/kg | Rat | dermal | acute | ECHA |
| LD50 | >16000 mg/kg | Rat | oral | - | ECHA |
| NOAEL | =1250 mg/kg-day | Rat | oral | chronic | EFSA |
| NOAEL | >1250 mg/kg-day | Rat | oral | chronic | ECHA |
| NOAEL | >1250 mg/kg-day | Rat | oral | subchronic | ECHA |
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
1 - 10 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Flavouring and nutrient
Humectant
Editorial summary
Preliminary editorial summary for Naringin — not a computed safety verdict. See the sourced toxicological data above.
Regulatory Flags
flavonoid
antioxidant
brightening
tyrosinase-inhibitor
UV-absorbing
anti-glycation
grapefruit
non-phototoxic
botanical
Known Synonyms
4H-1-Benzopyran-4-one, 7-((2-O-(6-deoxy-alpha-L-mannopyranosyl)-beta-D-glucopyranosyl)oxy)-2,3-dihydro-5-hydroxy-2-(4-hydroxyphenyl)-, (2S)-
4H-1-Benzopyran-4-one, 7-[[2-O-(6-deoxy-.alpha.-L-mannopyranosyl)-.beta.-D-glucopyranosyl]oxy]-2,3-dihydro-5-hydroxy-2-(4-hydroxyphenyl)-, (2S)-
EINECS 233-566-4
Naringenin-7-beta-neohesperidoside
5-Hydroxy-2-(4-hydroxyphenyl)-7-(2-O-alpha-L-rhamnopyranosyl-beta-D-glucopyranosyloxy)-4-chromanon
UNII-N7TD9J649B
Naringenin 7-O-[alpha-L-rhamnosyl-(1->2)-beta-D-glucoside]
Naringenin 7-O-alpha-L-rhamnosyl-(1->2)-beta-D-glucoside
Chemical Function
Humectant
Flavouring and nutrient
Regulatory Lists
Europe
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical and food safety data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
NARINGIN
ChEMBL ID
CHEMBL451532
SOURCE
EFSA / FDA GRAS
food_additives
Food Safety Data
Same-CAS food additive or FDA GRAS records from the core public database.
Food Name
Naringin
Food Category
preservative
Frequently Asked Questions
Is Naringin allowed in the EU?
Naringin EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Naringin do in cosmetics?
Naringin functions as: Skin protecting, Antioxidant, Skin brightening, UV absorbing. It is classified as a cosmetic ingredient in our database. CAS number: 10236-47-2.
Is Naringin used outside cosmetics?
Naringin also appears in industrial chemical safety, pharmaceutical, and food safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Naringin compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
Related Ingredients
1-Methylhydantoin-2-imide (Creatinine)
EXCELLENT
Similar safety
Skin conditioning (skin brightening/l...
2,6-Dimethyl-7-octen-2-ol (Dihydromyrcenol)
EXCELLENT
Similar safety
Fragrance (perfuming), masking
2-Ethoxy-2,6,6-Trimethyl-9-Methylenebicyclo[3.3.1]Nonane (Boisiris™)
EXCELLENT
Similar safety
Fragrance (rich woody, orris/iris roo...
2-Hydroxypropylcarbamato Amodimethicone
EXCELLENT
Similar safety
Hair conditioning; modified aminosili...
2-O-Ethyl Ascorbic Acid
EXCELLENT
Similar safety
Softener and conditioner
3 O Ethyl Ascorbic Acid
EXCELLENT
Similar safety
Antioxidant; tyrosinase inhibitor; me...
CI 18130
GOOD
Chemical family
Colorant
CI 77745 (Manganese Phosphate)
GOOD
Chemical family
Colorant. Inorganic pigment based on ...
NARCISSUS JONQUILLA CALLUS EXTRACT
GOOD
Browse nearby
Antimicrobial, Antioxidant, Hair Cond...
NARCISSUS JONQUILLA EXTRACT
GOOD
Browse nearby
Tonic
NARCISSUS JONQUILLA FLOWER OIL
GOOD
Browse nearby
Flavouring, Fragrance, Perfuming
NARCISSUS JONQUILLA FLOWER WATER
GOOD
Browse nearby
Flavouring, Fragrance, Perfuming, Ski...
(20S)-Protopanaxadiol
MODERATE
Same EU status
(AGARICUS BLAZEI FERMENT + GANODERMA LUCIDUM FERMENT + GANODERMA MULTIPILEUM FERMENT) EXTRACT
GOOD
Same EU status
Anti-sebum, Antioxidant, Skin Protecting
(ANGELICA ACUTILOBA/PAEONIA LACTIFLORA/REHMANNIA GLUTINOSA) ROOT/CNIDIUM OFFICINALE RHIZOME EXTRACT
GOOD
Same EU status
Skin Conditioning, Skin Conditioning ...
Is Naringin in Your Products?
Scan any product label with Piro — our free ingredient scanner. Point your camera at the ingredients list and get instant safety scores for every ingredient.
Try Piro Free →Analyze Your Full Ingredient List
Paste any INCI list into the Decoder for instant safety analysis, or calculate the Margin of Safety for Naringin in your formulation.