Good Cosmetic Ingredient Sensitization Data

Nerolidol

INCI: NEROLIDOL

CAS Number
7212-44-4
Function
Fragrance (woody, fresh bark aroma); skin conditioning agent; penetration enhancer
Safety Rating
GOOD

Regulatory Status

🇪🇺 EU Status permitted
🇺🇸 US Status permitted
US Notes FDA 21 CFR 172.515 (synthetic flavoring substance); FEMA GRAS 2772; no cosmetic-specific restrictions

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
high
Sensitization
moderate

Calculate MoS for your specific formulation with the MoS Calculator.

Sensitization Profile

Contact sensitization data for Nerolidol based on clinical patch test studies and IFRA standards.

Sensitization Rate
low
Allergen Class
fragrance
EU Allergen Listed
no
Patch Test Positive Rate
0.1%
Cross-reactivity Group
none
Reaction Type
contact-dermatitis

Source: IVDK; literature review

Expert Verdict

Permitted in EU with no concentration limits, but classified as skin sensitizer (H317) and aquatic toxic (H410); extreme penetration-enhancing capacity (198-fold increase) significantly increases dermal absorption of co-formulated ingredients.

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Concern Level: Moderate

Regulatory Flags

Allergen Environmental ifra_fragrance fda_food_additive jecfa_safe

Frequently Asked Questions

Is Nerolidol safe in cosmetics?

Permitted in EU with no concentration limits, but classified as skin sensitizer (H317) and aquatic toxic (H410); extreme penetration-enhancing capacity (198-fold increase) significantly increases dermal absorption of co-formulated ingredients. The EU classifies Nerolidol as "permitted". Safety rating: GOOD.

Is Nerolidol allowed in the EU?

Nerolidol EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Nerolidol do in cosmetics?

Nerolidol functions as: Fragrance (woody, fresh bark aroma); skin conditioning agent; penetration enhancer. It is classified as a cosmetic ingredient in our database. CAS number: 7212-44-4.

What is the Margin of Safety for Nerolidol?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

Compliance Tools

Check Nerolidol compliance across multiple jurisdictions:

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Ingredient Decoder
Paste a full ingredient list for instant analysis
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82 Allergen Checker
Check for EU declarable fragrance allergens
 🧪
Substance Compliance
Check compliance across 55 jurisdictions
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
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Heavy Metal Limits
Compare limits across jurisdictions

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