Good Cosmetic Ingredient NOAEL Data GHS Classified

NITROETHANE

CAS Number
79-24-3
Function
Solvent
Safety Rating
GOOD

Regulatory Status

🇪🇺 EU Status Permitted
🇺🇸 US Status prohibited
US Notes Not specifically listed as prohibited by FDA, but would fall under adulteration provisions if the product is unsafe; generally not used in cosmetics

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Toxicological Studies

2 study endpoints found for NITROETHANE. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint Value Route Species Study Type Source
NOEL 30 mg/kg bw/day oral rat oral REACH
NOAEL 48 2284 1991 rat inhalation REACH

GHS Hazard Classification

Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.

Signal Word
WARNING
Pictograms
flam;flame; excl mark;warn
Hazard Statements
Flammable liquid and vapour Harmful if swallowed or if inhaled
Short-term Exposure Effects
The substance is irritating to the eyes and respiratory tract. The substance may cause effects on the blood. This may result in the formation of methaemoglobin. Exposure at high levels could cause lowering of consciousness. The effects may be delayed. Medical observation is indicated.
Long-term Exposure Effects
The substance may have effects on the upper respiratory tract, blood, liver and kidneys.
Routes of Exposure
The substance can be absorbed into the body by inhalation of its vapour, by ingestion and through the skin.

Expert Verdict

NITROETHANE is listed in the EU CosIng database with functions: Solvent It is permitted in the EU without specific restrictions.

⚠️
Concern Level: Low

Regulatory Flags

cosing-sourced eu-permitted needs-enrichment

Frequently Asked Questions

Is NITROETHANE safe in cosmetics?

NITROETHANE is listed in the EU CosIng database with functions: Solvent It is permitted in the EU without specific restrictions. The EU classifies NITROETHANE as "Permitted". Safety rating: GOOD. 2 toxicological study endpoint(s) are available in our database.

Is NITROETHANE allowed in the EU?

NITROETHANE EU regulatory status: Permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does NITROETHANE do in cosmetics?

NITROETHANE functions as: Solvent. It is classified as a cosmetic ingredient in our database. CAS number: 79-24-3.

What is the NOAEL for NITROETHANE?

The NOAEL (No Observed Adverse Effect Level) for NITROETHANE is 30 mg/kg bw/day based on a oral study via oral route in rat. A total of 2 study endpoints are available. Source: REACH.

Is NITROETHANE classified as hazardous under GHS?

NITROETHANE carries a GHS signal word of "WARNING". Hazard statements: Flammable liquid and vapour Harmful if swallowed or if inhaled. This classification is based on the ILO/WHO International Chemical Safety Card and ECHA C&L inventory data. Note: GHS classification applies to the pure substance — at cosmetic use concentrations, hazard thresholds may not be met.

Compliance Tools

Check NITROETHANE compliance across multiple jurisdictions:

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Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
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Substance Compliance
Check compliance across 55 jurisdictions
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
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Heavy Metal Limits
Compare limits across jurisdictions

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