Good Surfactant NOAEL Data

PEG-2 Oleamine

INCI: PEG-2 OLEAMINE

CAS Number
25307-17-9
Function
Emulsifying Agent
Safety Rating
GOOD

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes CIR safe as used when formulated to be non-irritating (2018). 254 VCRP uses, mostly rinse-off hair colorants at up to 3.5%.

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
moderate
Sensitization
none

Calculate MoS for your specific formulation with the MoS Calculator.

Toxicological Studies

2 study endpoints found for PEG-2 Oleamine. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint Value Route Species Study Type Source
NOEL 5 mg/kg bw/day oral rat oral REACH
NOAEL 30 mg/kg bw/day oral rat oral REACH

Expert Verdict

CIR safe (2018) when formulated to be non-irritating. Nitrosamine formation potential must be controlled. 1,4-dioxane traces possible as ethoxylation impurity.

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Concern Level: Low

Frequently Asked Questions

Is PEG-2 Oleamine safe in cosmetics?

CIR safe (2018) when formulated to be non-irritating. Nitrosamine formation potential must be controlled. 1,4-dioxane traces possible as ethoxylation impurity. The EU classifies PEG-2 Oleamine as "permitted". Safety rating: GOOD. 2 toxicological study endpoint(s) are available in our database.

Is PEG-2 Oleamine allowed in the EU?

PEG-2 Oleamine EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does PEG-2 Oleamine do in cosmetics?

PEG-2 Oleamine functions as: Emulsifying Agent. It is classified as a Surfactant in our database. CAS number: 25307-17-9.

What is the Margin of Safety for PEG-2 Oleamine?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

What is the NOAEL for PEG-2 Oleamine?

The NOAEL (No Observed Adverse Effect Level) for PEG-2 Oleamine is 5 mg/kg bw/day based on a oral study via oral route in rat. A total of 2 study endpoints are available. Source: REACH.

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