Good Cosmetic Ingredient NOAEL Data

PEG-6 METHYL ETHER

CAS Number
9004-74-4
Function
Solvent
Safety Rating
GOOD

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status Permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status restricted
US Notes CIR: SQ - IJT 31(Suppl. 2):169-244, 2012

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Toxicological Studies

6 study endpoints found for PEG-6 METHYL ETHER. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint Value Route Species Study Type Source
NOAEL 4000 mg/kg bw/day dermal rat dermal REACH
LOAEL 1200 mg/kg bw/day oral rat oral REACH
NOAEL 94 2104 1991 rat inhalation REACH
NOAEL 250 mg/kg bw/day oral rat oral REACH
NOAEL >1000 mg/kg bw/day dermal code:3484 dermal REACH
NOAEL 350 other 1991 rat inhalation REACH

Expert Verdict

PEG-6 METHYL ETHER is listed in the EU CosIng database with functions: Solvent It is permitted in the EU without specific restrictions.

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Concern Level: Low

Regulatory Flags

cosing-sourced eu-permitted needs-enrichment epa_safer_alternative

Frequently Asked Questions

Is PEG-6 METHYL ETHER safe in cosmetics?

PEG-6 METHYL ETHER is listed in the EU CosIng database with functions: Solvent It is permitted in the EU without specific restrictions. The EU classifies PEG-6 METHYL ETHER as "Permitted". Safety rating: GOOD. 6 toxicological study endpoint(s) are available in our database.

Is PEG-6 METHYL ETHER allowed in the EU?

PEG-6 METHYL ETHER EU regulatory status: Permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does PEG-6 METHYL ETHER do in cosmetics?

PEG-6 METHYL ETHER functions as: Solvent. It is classified as a cosmetic ingredient in our database. CAS number: 9004-74-4.

What is the NOAEL for PEG-6 METHYL ETHER?

The NOAEL (No Observed Adverse Effect Level) for PEG-6 METHYL ETHER is 4000 mg/kg bw/day based on a dermal study via dermal route in rat. A total of 6 study endpoints are available. Source: REACH.

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