Moderate Cosmetic Ingredient NOAEL Data GHS Classified

STYRENE

CAS Number
100-42-5
Function
Solvent
Safety Rating
MODERATE

Regulatory Status

🇪🇺 EU Status Restricted
EU Max Conc. II/1575
🇺🇸 US Status Not specifically regulated

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Toxicological Studies

10 study endpoints found for STYRENE. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint Value Route Species Study Type Source
NOAEL 400 mg/kg bw/day oral dog Chronic COSMOS_DB
NOAEL 1000 mg/kg bw/day oral rat Carcinogenicity COSMOS_DB
NOAEL 300 mg/kg bw/day oral mouse Carcinogenicity COSMOS_DB
NOAEL 300 mg/kg bw/day oral rat Developmental COSMOS_DB
NOAEL 500 mg/kg bw/day oral rat Short Term Toxicity COSMOS_DB
NOAEL 500 mg/kg bw/day oral rat Subchronic COSMOS_DB
NOAEL 400 mg/kg bw/day oral rat Subchronic COSMOS_DB
NOAEL 34.6 mg/kg bw/day oral rat Short Term Toxicity COSMOS_DB
NOAEL 2150 mg/kg bw/day oral rat Subchronic COSMOS_DB
NOAEL 464 mg/kg bw/day oral mouse Subchronic COSMOS_DB

GHS Hazard Classification

Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.

Signal Word
DANGER
Pictograms
flam;flame; excl mark;warn; cancer;health haz
Hazard Statements
Flammable liquid and vapour Harmful if inhaled Causes skin and eye irritation Suspected of causing cancer Causes damage to the central nervous system and the liver through prolonged or repeated exposure Toxic to aquatic life
Short-term Exposure Effects
The substance is irritating to the eyes, skin and respiratory tract. If this liquid is swallowed, aspiration into the lungs may result in chemical pneumonitis. The substance may cause effects on the central nervous system. Exposure at high levels could cause unconsciousness.
Long-term Exposure Effects
The substance defats the skin, which may cause dryness or cracking. The substance may have effects on the central nervous system. Exposure to the substance may increase noise-induced hearing loss. This substance is possibly carcinogenic to humans. See Notes.
Routes of Exposure
The substance can be absorbed into the body by inhalation of its vapour.

Expert Verdict

STYRENE is listed in the EU CosIng database with functions: Solvent It is restricted under EU Cosmetics Regulation. Restriction: II/1575.

⚠️
Concern Level: Medium

Regulatory Flags

cosing-sourced eu-restricted needs-enrichment endocrine_disruptor prop65 eu_banned_cosmetics ifra_fragrance fda_food_additive eu_cosing_listed

Frequently Asked Questions

Is STYRENE safe in cosmetics?

STYRENE is listed in the EU CosIng database with functions: Solvent It is restricted under EU Cosmetics Regulation. Restriction: II/1575. The EU classifies STYRENE as "Restricted". Safety rating: MODERATE. 10 toxicological study endpoint(s) are available in our database.

Is STYRENE allowed in the EU?

STYRENE EU regulatory status: Restricted. Maximum allowed concentration: II/1575. This is based on EU Regulation 1223/2009 and its amendments.

What does STYRENE do in cosmetics?

STYRENE functions as: Solvent. It is classified as a cosmetic ingredient in our database. CAS number: 100-42-5.

What is the NOAEL for STYRENE?

The NOAEL (No Observed Adverse Effect Level) for STYRENE is 400 mg/kg bw/day based on a Chronic study via oral route in dog. A total of 10 study endpoints are available. Source: COSMOS_DB.

Is STYRENE classified as hazardous under GHS?

STYRENE carries a GHS signal word of "DANGER". Hazard statements: Flammable liquid and vapour Harmful if inhaled Causes skin and eye irritation Suspected of causing cancer Causes damage to the central nervous system and the liver through prolonged or repeated exposure Toxic to aquatic life. This classification is based on the ILO/WHO International Chemical Safety Card and ECHA C&L inventory data. Note: GHS classification applies to the pure substance — at cosmetic use concentrations, hazard thresholds may not be met.

Compliance Tools

Check STYRENE compliance across multiple jurisdictions:

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Ingredient Decoder
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82 Allergen Checker
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Substance Compliance
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MoS Calculator
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