Pentapeptide-5

INCI: PENTAPEPTIDE-5

CAS Number
SH-Pentapeptide-5 (Leu-enkephalin variant): 58822-25-6 ; base Pentapeptide-5 CAS not separately listed
Function
Skin conditioning
Safety Rating
MODERATE

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes Not listed as prohibited or restricted by FDA

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
moderate
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

SH-Pentapeptide-5 is a Leu-enkephalin variant with endogenous opioid peptide activity; biological activity requires safety justification.

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Concern Level: Moderate

Frequently Asked Questions

Is Pentapeptide-5 safe in cosmetics?

SH-Pentapeptide-5 is a Leu-enkephalin variant with endogenous opioid peptide activity; biological activity requires safety justification. The EU classifies Pentapeptide-5 as "permitted". Safety rating: MODERATE.

Is Pentapeptide-5 allowed in the EU?

Pentapeptide-5 EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Pentapeptide-5 do in cosmetics?

Pentapeptide-5 functions as: Skin conditioning. It is classified as a cosmetic ingredient in our database. CAS number: SH-Pentapeptide-5 (Leu-enkephalin variant): 58822-25-6 ; base Pentapeptide-5 CAS not separately listed.

What is the Margin of Safety for Pentapeptide-5?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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