SH-Decapeptide-1 SH-Polypeptide-9
INCI: SH-DECAPEPTIDE-1 SH-POLYPEPTIDE-9
Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Expert Verdict
🔴 CRITICAL: VEGFA activity can contribute to progression of psoriasis — contraindicated for individuals with psoriatic skin. Not recommended after sunburn or high-dose UV exposure. Increases vascular permeability which may exacerbate edema or inflammatory conditions. This is the highest-risk ingredient in this set
Frequently Asked Questions
Is SH-Decapeptide-1 SH-Polypeptide-9 safe in cosmetics?
🔴 CRITICAL: VEGFA activity can contribute to progression of psoriasis — contraindicated for individuals with psoriatic skin. Not recommended after sunburn or high-dose UV exposure. Increases vascular permeability which may exacerbate edema or inflammatory conditions. This is the highest-risk ingredient in this set The EU classifies SH-Decapeptide-1 SH-Polypeptide-9 as "permitted". Safety rating: MODERATE.
Is SH-Decapeptide-1 SH-Polypeptide-9 allowed in the EU?
SH-Decapeptide-1 SH-Polypeptide-9 EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does SH-Decapeptide-1 SH-Polypeptide-9 do in cosmetics?
SH-Decapeptide-1 SH-Polypeptide-9 functions as: Skin Conditioning, Hair Growth Stimulation, Microcirculation Enhancement; the SH-Polypeptide-9 component is a recombinant analog of VEGFA (Vascular Endothelial Growth Factor A). It is classified as a cosmetic ingredient in our database. CAS number: SH-Polypeptide-9 component: 127464-60-2 ; fusion peptide CAS: not assigned.
What is the Margin of Safety for SH-Decapeptide-1 SH-Polypeptide-9?
not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
Compliance Tools
Check SH-Decapeptide-1 SH-Polypeptide-9 compliance across multiple jurisdictions:
Related Ingredients
Is SH-Decapeptide-1 SH-Polypeptide-9 in Your Products?
Scan any product label with Piro — our free ingredient scanner. Point your camera at the ingredients list and get instant safety scores for every ingredient.
Try Piro Free →Analyze Your Full Ingredient List
Paste any INCI list into the Decoder for instant safety analysis, or calculate the Margin of Safety for SH-Decapeptide-1 SH-Polypeptide-9 in your formulation.