Poor Cosmetic Ingredient NOAEL Data

Perfluorooctylethyl Triethoxysilane

INCI: PERFLUOROOCTYLETHYL TRIETHOXYSILANE

CAS Number
51851-37-7
Function
Surface modifier, hydrophobic coating agent
Safety Rating
POOR

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status prohibited
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes No specific FDA ban; MoCRA PFAS review ongoing

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
low
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Toxicological Studies

1 study endpoint found for Perfluorooctylethyl Triethoxysilane. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint Value Route Species Study Type Source
NOAEL 50 mg/kg bw/day oral rat oral REACH

Expert Verdict

Flagged by ECHA enforcement as non-compliant in cosmetics; direct PFOA precursor with C8 chain; France banned January 2026.

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Concern Level: High

Frequently Asked Questions

Is Perfluorooctylethyl Triethoxysilane safe in cosmetics?

Flagged by ECHA enforcement as non-compliant in cosmetics; direct PFOA precursor with C8 chain; France banned January 2026. The EU classifies Perfluorooctylethyl Triethoxysilane as "prohibited". Safety rating: POOR. 1 toxicological study endpoint(s) are available in our database.

Is Perfluorooctylethyl Triethoxysilane allowed in the EU?

Perfluorooctylethyl Triethoxysilane EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.

What does Perfluorooctylethyl Triethoxysilane do in cosmetics?

Perfluorooctylethyl Triethoxysilane functions as: Surface modifier, hydrophobic coating agent. It is classified as a cosmetic ingredient in our database. CAS number: 51851-37-7.

What is the Margin of Safety for Perfluorooctylethyl Triethoxysilane?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

What is the NOAEL for Perfluorooctylethyl Triethoxysilane?

The NOAEL (No Observed Adverse Effect Level) for Perfluorooctylethyl Triethoxysilane is 50 mg/kg bw/day based on a oral study via oral route in rat. Source: REACH.

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