Perillyl Alcohol

INCI: PERILLYL ALCOHOL

CAS Number
536-59-4 (racemic); 18457-55-1 (S-enantiomer)
Function
Fragrance
Safety Rating
MODERATE

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status restricted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes FEMA GRAS for flavoring. FDA permits in cosmetics as fragrance ingredient; no specific limit

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
moderate
Sensitization
moderate

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

H315/H319/H335 classification. Metabolized to perillic acid in vivo. Investigated as chemotherapeutic agent with pharmacological activity at high doses. In cosmetic concentrations (fragrance-level), irritation risk is primary concern. Auto-oxidation products may increase sensitization potential over time.

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Concern Level: Moderate

Regulatory Flags

potential-allergen fragrance-component

Frequently Asked Questions

Is Perillyl Alcohol safe in cosmetics?

H315/H319/H335 classification. Metabolized to perillic acid in vivo. Investigated as chemotherapeutic agent with pharmacological activity at high doses. In cosmetic concentrations (fragrance-level), irritation risk is primary concern. Auto-oxidation products may increase sensitization potential over time. The EU classifies Perillyl Alcohol as "restricted". Safety rating: MODERATE.

Is Perillyl Alcohol allowed in the EU?

Perillyl Alcohol EU regulatory status: restricted. This is based on EU Regulation 1223/2009 and its amendments.

What does Perillyl Alcohol do in cosmetics?

Perillyl Alcohol functions as: Fragrance. It is classified as a cosmetic ingredient in our database. CAS number: 536-59-4 (racemic); 18457-55-1 (S-enantiomer).

What is the Margin of Safety for Perillyl Alcohol?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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