Is Sodium Anisate safe in cosmetics?
Sodium Anisate has a safety rating of "MODERATE" in our database. EU status: permitted. US status: permitted.
Moderate
Cosmetic Ingredient
Sodium Anisate
Also known as: EINECS 208-634-1, UNII-F9WFJ28MV9
INCI: SODIUM ANISATE
Sodium Anisate (CAS 536-45-8) is a cosmetic cosmetic ingredient functioning as Antimicrobial, flavouring, fragrance, pH adjuster, anti-inflammatory, fungicidal. NOAEL 20 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 536-45-8 →
Auto-generated CPSR Part A draft with source citations
Function
Antimicrobial, flavouring, fragrance, pH adjuster, anti-inflammatory, fungicidal
Safety Rating
MODERATE
Chemistry & Identifiers
IUPAC Name
sodium 4-methoxybenzoate
InChIKey
AETSDHMVQHOYPB-UHFFFAOYSA-M
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
No specific FDA restrictions; no dedicated CIR safety assessment published
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Sodium Anisate.
Calculate MoS for your specific formulation with the MoS Calculator.
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for Sodium Anisate across SCCS product categories, with measured dermal absorption where available.
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
10 - 100 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Additional Ingredient Properties
5 property records from structured ingredient metadata.
acne
{"cas_number": "536-45-8", "anti_acne_mechanism": "antibacterial", "comedogenicity_rating_0_to_5": "0-1", "acne_type_efficacy": "inflammatory", "p_acnes_mic_ug_per_ml": ">500", "sebum_reduction_pct_clinical": "0-5", "prescription_required_usa": "No", "otc_drug_monograph_category": "No", "max_otc_concentration_pct": "Max 1-2%", "japan_quasi_drug_anti_acne": "No", "korea_functional_cosmetic_acne": "…
baby_pediatric
{"cas_number": "536-45-8", "ingredient_class": "preservative_baby_safe", "pediatric_safety_rating": "good", "minimum_age_months": "0", "neonatal_safe": "yes", "premature_infant_safe": "yes", "skin_barrier_maturity_consideration": "Natural anise-derived, antimicrobial booster", "transepidermal_absorption_risk_pediatric": "low", "dose_per_kg_body_weight_concern": "Safe", "skin_surface_area_to_weight…
pregnancy_detail
{"pregnancy_safe": "yes", "breastfeeding_safe": "yes", "risk_category": "not-rated", "reason": "Natural preservative; COSMOS approved", "source": "COSMOS"}
preservative
{"preservative_class": "Organic acid", "antimicrobial_spectrum_bacteria_gp": "Moderate", "antimicrobial_spectrum_bacteria_gn": "Moderate", "antimicrobial_spectrum_yeast": "Moderate", "antimicrobial_spectrum_mold": "Moderate", "mic_staph_aureus_ppm": "900", "mic_e_coli_ppm": "1050", "mic_pseudomonas_ppm": "1200", "mic_candida_albicans_ppm": "1700", "mic_aspergillus_niger_ppm": "2500", "challenge_te…
solubility_hlb
{"water_soluble": "yes", "oil_soluble": "no", "soluble_in": "water, propylene glycol", "insoluble_in": "oils, ethanol, silicones", "log_p": "-1.5", "appearance": "white powder", "source": "Caregen"}
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Biocide
Flavouring and nutrient
Expert Verdict
Expert safety assessment and concern-level summary for Sodium Anisate.
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to Sodium Anisate by CAS number or substance name.
Studies
6
Lowest NOAEL
20 mg/kg bw/day
Highest NOAEL
500 mg/kg bw/day
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip
Known Synonyms
EINECS 208-634-1
UNII-F9WFJ28MV9
Chemical Function
Biocide
Flavouring and nutrient
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL1762657
Frequently Asked Questions
Is Sodium Anisate allowed in the EU?
Sodium Anisate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Sodium Anisate do in cosmetics?
Sodium Anisate functions as: Antimicrobial, flavouring, fragrance, pH adjuster, anti-inflammatory, fungicidal. It is classified as a cosmetic ingredient in our database. CAS number: 536-45-8.
Is Sodium Anisate used outside cosmetics?
Sodium Anisate also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Sodium Anisate compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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