Moderate Cosmetic Ingredient NOAEL Data

Phenoxyethyl Acrylate

INCI: PHENOXYETHYL ACRYLATE

CAS Number
48145-04-6
Function
Film former / monomer for cosmetic polymers
Safety Rating
MODERATE

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes CIR reviewed acrylates group โ€” safe when formulated to avoid irritation; for monomers, directions to avoid skin contact recommended

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
moderate
Sensitization
high

Calculate MoS for your specific formulation with the MoS Calculator.

Toxicological Studies

3 study endpoints found for Phenoxyethyl Acrylate. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint Value Route Species Study Type Source
NOAEL 300 mg/kg bw/day oral rat oral REACH
NOAEL 350 mg/kg bw/day oral rat oral REACH
NOAEL 500 mg/kg bw/day oral rat oral REACH

Expert Verdict

Must not be used as free monomer on skin. Residual monomer in polymer formulations must be minimised. Safe when application is accompanied by directions to avoid skin contact for related monomers. Primarily acceptable in nail products or as polymerised form only.

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Concern Level: High

Frequently Asked Questions

Is Phenoxyethyl Acrylate safe in cosmetics?

Must not be used as free monomer on skin. Residual monomer in polymer formulations must be minimised. Safe when application is accompanied by directions to avoid skin contact for related monomers. Primarily acceptable in nail products or as polymerised form only. The EU classifies Phenoxyethyl Acrylate as "permitted". Safety rating: MODERATE. 3 toxicological study endpoint(s) are available in our database.

Is Phenoxyethyl Acrylate allowed in the EU?

Phenoxyethyl Acrylate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Phenoxyethyl Acrylate do in cosmetics?

Phenoxyethyl Acrylate functions as: Film former / monomer for cosmetic polymers. It is classified as a cosmetic ingredient in our database. CAS number: 48145-04-6.

What is the Margin of Safety for Phenoxyethyl Acrylate?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

What is the NOAEL for Phenoxyethyl Acrylate?

The NOAEL (No Observed Adverse Effect Level) for Phenoxyethyl Acrylate is 300 mg/kg bw/day based on a oral study via oral route in rat. A total of 3 study endpoints are available. Source: REACH.

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