Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
7 study endpoints found for Phenylacetic Acid. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 45 mg/kg bw/day | oral | rat | Developmental | COSMOS_DB |
| NOAEL | 450 mg/kg bw/day | oral | rat | Developmental | COSMOS_DB |
| NOAEL | 5 mg/kg bw/day | oral | rat | Developmental | COSMOS_DB |
| LOAEL | 45 mg/kg bw/day | oral | rat | Developmental | COSMOS_DB |
| NOEL | 1000 other | other | mouse | oral | REACH |
| NOAEL | >1000 mg/kg bw/day | oral | rat | oral | REACH |
| NOAEL | 1000 mg/kg bw/day | oral | rat | oral | REACH |
GHS Hazard Classification
Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.
Expert Verdict
Phenylacetic acid is a restricted fragrance ingredient with skin, eye, and respiratory irritant properties (H315, H319, H335); it is also a DEA List II monitored precursor chemical.
Regulatory Flags
Frequently Asked Questions
Is Phenylacetic Acid safe in cosmetics?
Phenylacetic acid is a restricted fragrance ingredient with skin, eye, and respiratory irritant properties (H315, H319, H335); it is also a DEA List II monitored precursor chemical. The EU classifies Phenylacetic Acid as "restricted". Safety rating: GOOD. 7 toxicological study endpoint(s) are available in our database.
Is Phenylacetic Acid allowed in the EU?
Phenylacetic Acid EU regulatory status: restricted. This is based on EU Regulation 1223/2009 and its amendments.
What does Phenylacetic Acid do in cosmetics?
Phenylacetic Acid functions as: Perfuming (fragrance ingredient). It is classified as a cosmetic ingredient in our database. CAS number: 103-82-2.
What is the Margin of Safety for Phenylacetic Acid?
adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Phenylacetic Acid?
The NOAEL (No Observed Adverse Effect Level) for Phenylacetic Acid is 45 mg/kg bw/day based on a Developmental study via oral route in rat. A total of 7 study endpoints are available. Source: COSMOS_DB.
Is Phenylacetic Acid classified as hazardous under GHS?
Phenylacetic Acid carries a GHS signal word of "WARNING". Hazard statements: Causes mild skin irritation Causes eye irritation Harmful to aquatic life. This classification is based on the ILO/WHO International Chemical Safety Card and ECHA C&L inventory data. Note: GHS classification applies to the pure substance — at cosmetic use concentrations, hazard thresholds may not be met.
Compliance Tools
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Related Ingredients
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