Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Expert Verdict
Not permitted for cosmetic use. Phenylmethylsulfonyl fluoride is a biochemistry laboratory reagent and irreversible serine protease inhibitor that causes severe skin burns and eye damage, decomposes to produce hydrofluoric acid, and is fatal if misused.
Frequently Asked Questions
Is Phenylmethylsulfonyl Fluoride safe in cosmetics?
Not permitted for cosmetic use. Phenylmethylsulfonyl fluoride is a biochemistry laboratory reagent and irreversible serine protease inhibitor that causes severe skin burns and eye damage, decomposes to produce hydrofluoric acid, and is fatal if misused. The EU classifies Phenylmethylsulfonyl Fluoride as "prohibited". Safety rating: POOR.
Is Phenylmethylsulfonyl Fluoride allowed in the EU?
Phenylmethylsulfonyl Fluoride EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.
What does Phenylmethylsulfonyl Fluoride do in cosmetics?
Phenylmethylsulfonyl Fluoride functions as: Serine protease inhibitor (laboratory reagent only). It is classified as a cosmetic ingredient in our database. CAS number: 329-98-6 [^1_3].
What is the Margin of Safety for Phenylmethylsulfonyl Fluoride?
not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
Compliance Tools
Check Phenylmethylsulfonyl Fluoride compliance across multiple jurisdictions:
Related Ingredients
Is Phenylmethylsulfonyl Fluoride in Your Products?
Scan any product label with Piro โ our free ingredient scanner. Point your camera at the ingredients list and get instant safety scores for every ingredient.
Try Piro Free โAnalyze Your Full Ingredient List
Paste any INCI list into the Decoder for instant safety analysis, or calculate the Margin of Safety for Phenylmethylsulfonyl Fluoride in your formulation.