Phenylmethylsulfonyl Fluoride

INCI: NOT A COSMETIC INGREDIENT

CAS Number
329-98-6 [^1_3]
Function
Serine protease inhibitor (laboratory reagent only)
Safety Rating
POOR

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status prohibited
๐Ÿ‡บ๐Ÿ‡ธ US Status prohibited
US Notes FDA does not authorize cosmetic use; classified as laboratory chemical

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
low
Sensitization
high

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Not permitted for cosmetic use. Phenylmethylsulfonyl fluoride is a biochemistry laboratory reagent and irreversible serine protease inhibitor that causes severe skin burns and eye damage, decomposes to produce hydrofluoric acid, and is fatal if misused.

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Concern Level: High

Frequently Asked Questions

Is Phenylmethylsulfonyl Fluoride safe in cosmetics?

Not permitted for cosmetic use. Phenylmethylsulfonyl fluoride is a biochemistry laboratory reagent and irreversible serine protease inhibitor that causes severe skin burns and eye damage, decomposes to produce hydrofluoric acid, and is fatal if misused. The EU classifies Phenylmethylsulfonyl Fluoride as "prohibited". Safety rating: POOR.

Is Phenylmethylsulfonyl Fluoride allowed in the EU?

Phenylmethylsulfonyl Fluoride EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.

What does Phenylmethylsulfonyl Fluoride do in cosmetics?

Phenylmethylsulfonyl Fluoride functions as: Serine protease inhibitor (laboratory reagent only). It is classified as a cosmetic ingredient in our database. CAS number: 329-98-6 [^1_3].

What is the Margin of Safety for Phenylmethylsulfonyl Fluoride?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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