Is Phosphatidylserine safe in cosmetics?
Phosphatidylserine has a safety rating of "EXCELLENT" in our database. EU status: permitted. US status: permitted.
Excellent
Cosmetic Ingredient
Phosphatidylserine
Also known as: 4,6,10-Trioxa-5-phosphaoctacosanoic acid, 2-amino-5-hydroxy-11-oxo-8-[(1-oxooctadecyl)oxy]-, 5-oxide, (2S,8R)-, L-Serine, (2R)-2,3-bis[(1-oxooctadecyl)oxy]propyl hydrogen phosphate (ester), L-Serine, 2,3-bis[(1-oxooctadecyl)oxy]propyl hydrogen phosphate (ester), (R)-, 1,2-Distearoyl-sn-3-glycerophosphoserine, 1,2-Distearoyl-sn-glycero-3-phosphatidylserine (+3 more)
INCI: PHOSPHATIDYLSERINE
Phosphatidylserine (CAS 51446-62-9) is a cosmetic cosmetic ingredient functioning as Skin conditioning agent. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety data.
View industrial chemical safety profile for CAS 51446-62-9 →
Auto-generated CPSR Part A draft with source citations
Function
Skin conditioning agent
Safety Rating
EXCELLENT
Chemistry & Identifiers
IUPAC Name
(2S)-2-amino-3-[[(2R)-2,3-di(octadecanoyloxy)propoxy]-hydroxyphosphoryl]oxypropanoic acid
InChIKey
TZCPCKNHXULUIY-RGULYWFUSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
CIR safe in present practices of use and concentration; FDA GRAS (food)
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Phosphatidylserine.
Calculate MoS for your specific formulation with the MoS Calculator.
Additional Ingredient Properties
4 property records from structured ingredient metadata.
anti_aging
{"anti_aging_claim": "barrier-repair, anti-inflammatory", "mechanism_of_action": "Lipid barrier restoration, TEWL reduction, emollient", "target_skin_layer": "stratum corneum", "collagen_stimulation": "No", "elastin_protection": "No", "wrinkle_reduction_pct": "8-15", "clinical_study_duration_weeks": "8", "sample_size": "30", "double_blind": "No", "placebo_controlled": "Yes", "published_journal": "…
emulsifier
{"cas_number": "51446-62-9", "ingredient_class": "O/W_emulsifier,liquid_crystal_former", "chemical_type": "lecithin", "HLB_value": "9.0", "HLB_required_for_oil_phase": "8-10", "emulsion_type_primary": "O/W", "droplet_size_typical_um": "5-15", "surface_tension_reduction_mN_m": "31", "interfacial_tension_reduction": "35", "foam_formation": "low", "foam_stability": "low", "liquid_crystal_formation": …
emulsion_hlb
{"hlb_required_as_emulsifier": "yes", "emulsifier_type": "o_w", "critical_packing_parameter": "0.28-0.42", "emulsion_stabilization_mechanism": "electrostatic_steric", "co_emulsifier_pairs": "xanthan_gum", "optimal_oil_phase_pct": "10-30", "optimal_water_phase_pct": "70-90", "electrolyte_tolerance": "very_low", "pH_emulsion_stability_range": "4.0-7.5", "viscosity_building_contribution": "low-modera…
surfactant
{"cas_number": "53402-66-6", "surfactant_type": "nonionic", "chemical_class": "fatty_acid_soap", "charge_at_use_ph": "neutral", "cmc_critical_micelle_concentration_mm": "4.724392749578375", "hlb_value": "24.021456275148786", "foam_volume_ml_ross_miles": "125", "foam_quality": "creamy", "foam_stability_5min_pct": "81", "cleansing_power_rating_1_to_10": "8.639836693594397", "oil_emulsification_capac…
Expert Verdict
Expert safety assessment and concern-level summary for Phosphatidylserine.
Regulatory Flags
potential-allergen
Known Synonyms
4,6,10-Trioxa-5-phosphaoctacosanoic acid, 2-amino-5-hydroxy-11-oxo-8-[(1-oxooctadecyl)oxy]-, 5-oxide, (2S,8R)-
L-Serine, (2R)-2,3-bis[(1-oxooctadecyl)oxy]propyl hydrogen phosphate (ester)
L-Serine, 2,3-bis[(1-oxooctadecyl)oxy]propyl hydrogen phosphate (ester), (R)-
1,2-Distearoyl-sn-3-glycerophosphoserine
1,2-Distearoyl-sn-glycero-3-phosphatidylserine
CERAPP_40662
DSPS
Distearoylphosphatidylserine
Frequently Asked Questions
Is Phosphatidylserine allowed in the EU?
Phosphatidylserine EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Phosphatidylserine do in cosmetics?
Phosphatidylserine functions as: Skin conditioning agent. It is classified as a cosmetic ingredient in our database. CAS number: 51446-62-9.
Is Phosphatidylserine used outside cosmetics?
Phosphatidylserine also appears in industrial chemical safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Phosphatidylserine compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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