Is Polypeptide-1 safe in cosmetics?
Polypeptide-1 has a safety rating of "EXCELLENT" in our database. EU status: permitted. US status: permitted.
EXCELLENT
Cosmetic Ingredient
Polypeptide-1
INCI: POLYPEPTIDE-1
Polypeptide-1 is a cosmetic cosmetic ingredient functioning as Skin Conditioning. EU Regulation 1223/2009 status: permitted.
Function
Skin Conditioning
Editorial assessment
EXCELLENT
Preliminary editorial note — not a computed safety verdict.
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Synthetic peptide of 153 amino acids; no specific FDA restrictions; CIR tissue-derived protein assessment supports safety
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Polypeptide-1.
Calculate MoS for your specific formulation with the MoS Calculator.
Editorial summary
Preliminary editorial summary for Polypeptide-1 — not a computed safety verdict. See the sourced toxicological data above.
Regulatory Flags
synthetic-peptide
skin-conditioning
anti-aging
Frequently Asked Questions
Is Polypeptide-1 allowed in the EU?
Polypeptide-1 EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Polypeptide-1 do in cosmetics?
Polypeptide-1 functions as: Skin Conditioning. It is classified as a cosmetic ingredient in our database.
Compliance Tools
Check Polypeptide-1 compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
Related Ingredients
Polypeptide-11
EXCELLENT
Same category
Skin Conditioning, Hair Conditioning
1-Methylhydantoin-2-imide (Creatinine)
EXCELLENT
Similar safety
Skin conditioning (skin brightening/l...
2,6-Dimethyl-7-octen-2-ol (Dihydromyrcenol)
EXCELLENT
Similar safety
Fragrance (perfuming), masking
2-Ethoxy-2,6,6-Trimethyl-9-Methylenebicyclo[3.3.1]Nonane (Boisiris™)
EXCELLENT
Similar safety
Fragrance (rich woody, orris/iris roo...
2-Hydroxypropylcarbamato Amodimethicone
EXCELLENT
Similar safety
Hair conditioning; modified aminosili...
2-O-Ethyl Ascorbic Acid
EXCELLENT
Similar safety
Softener and conditioner
3 O Ethyl Ascorbic Acid
EXCELLENT
Similar safety
Antioxidant; tyrosinase inhibitor; me...
POLY 1,2-BUTANEDIOL-6 PROPYLENE GLYCOL
GOOD
Browse nearby
Solvent
POLY METHYL STYRENE ISOPROPANOL KETONE
GOOD
Browse nearby
Light Stabilizer
POLY(1-4 BUTANEDIOL)-27
GOOD
Browse nearby
Not Reported
POLYCHLOROTRIFLUOROETHYLENE
GOOD
Browse nearby
Film Forming, Skin Conditioning
(20S)-Protopanaxadiol
MODERATE
Same EU status
(AGARICUS BLAZEI FERMENT + GANODERMA LUCIDUM FERMENT + GANODERMA MULTIPILEUM FERMENT) EXTRACT
GOOD
Same EU status
Anti-sebum, Antioxidant, Skin Protecting
(ANGELICA ACUTILOBA/PAEONIA LACTIFLORA/REHMANNIA GLUTINOSA) ROOT/CNIDIUM OFFICINALE RHIZOME EXTRACT
GOOD
Same EU status
Skin Conditioning, Skin Conditioning ...
(ANGELICA ACUTILOBA/PAEONIA LACTIFLORA/REHMANNIA GLUTINOSA/SCUTELLARIA BAICALENSIS) ROOT/(CNIDIUM OFFICINALE/COPTIS CHINENSIS) RHIZOME/GARDENIA JASMINOIDES FRUIT/PHELLODENDRON CHINENSE BARK EXTRACT
GOOD
Same EU status
Is Polypeptide-1 in Your Products?
Scan any product label with Piro — our free ingredient scanner. Point your camera at the ingredients list and get instant safety scores for every ingredient.
Try Piro Free →Analyze Your Full Ingredient List
Paste any INCI list into the Decoder for instant safety analysis, or calculate the Margin of Safety for Polypeptide-1 in your formulation.