Is Polypeptide-11 safe in cosmetics?
Polypeptide-11 has a safety rating of "EXCELLENT" in our database. EU status: permitted. US status: permitted.
Excellent
Cosmetic Ingredient
Polypeptide-11
INCI: POLYPEPTIDE-11
Polypeptide-11 (CAS 62031-54-3) is a cosmetic cosmetic ingredient functioning as Skin Conditioning, Hair Conditioning. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database.
View industrial chemical safety profile for CAS 62031-54-3 →
Auto-generated CPSR Part A draft with source citations
Function
Skin Conditioning, Hair Conditioning
Safety Rating
EXCELLENT
Chemistry & Identifiers
IUPAC Name
(2R)-N-[(2R)-1-[[(2R)-6-amino-1-[[(2R)-6-amino-1-[(2R)-2-(hydroxymethyl)pyrrolidin-1-yl]-1-oxohexan-2-yl]amino]-1-oxohexan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]-2-[[2-[[(2R)-2-[[(2R)-1-[(2R)-2-[[(2R)-4-amino-2-[[(2R)-2-amino-3-phenylpropanoyl]amino]-4-oxobutanoyl]amino]-4-methylpentanoyl]pyrrolidine-2-carbonyl]amino]-4-methylpentanoyl]amino]acetyl]amino]butanediamide
InChIKey
MSJSNXQCIRMHFJ-WIRNGOBFSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Synthetic recombinant analog of acidic Fibroblast Growth Factor (aFGF/FGF1); used in anti-aging and hair growth formulations; no specific FDA restrictions
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Polypeptide-11.
Calculate MoS for your specific formulation with the MoS Calculator.
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Softener and conditioner
Expert Verdict
Expert safety assessment and concern-level summary for Polypeptide-11.
Regulatory Flags
growth-factor-analog
synthetic-peptide
anti-aging
hair-growth
Chemical Function
Softener and conditioner
Frequently Asked Questions
Is Polypeptide-11 allowed in the EU?
Polypeptide-11 EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Polypeptide-11 do in cosmetics?
Polypeptide-11 functions as: Skin Conditioning, Hair Conditioning. It is classified as a cosmetic ingredient in our database. CAS number: 62031-54-3.
Compliance Tools
Check Polypeptide-11 compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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rh-Polypeptide-11
Good
Chemical family
Skin conditioning, skin protecting; r...
POLY 1,2-BUTANEDIOL-6 PROPYLENE GLYCOL
Good
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Solvent
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Good
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Light Stabilizer
POLY(1-4 BUTANEDIOL)-27
Good
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Not Reported
POLYCHLOROTRIFLUOROETHYLENE
Good
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Film Forming, Skin Conditioning
(20S)-Protopanaxadiol
Moderate
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Good
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Anti-sebum, Antioxidant, Skin Protecting
(ANGELICA ACUTILOBA/PAEONIA LACTIFLORA/REHMANNIA GLUTINOSA) ROOT/CNIDIUM OFFICINALE RHIZOME EXTRACT
Good
Same EU status
Skin Conditioning, Skin Conditioning ...
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