Poor Cosmetic Ingredient NOAEL Data GHS Classified

Potassium Chlorate

INCI: POTASSIUM CHLORATE

CAS Number
3811-04-9
Function
Oxidising agent (historically in oral care products)
Safety Rating
POOR

Regulatory Status

🇪🇺 EU Status restricted
EU Max Conc. 5%
🇺🇸 US Status restricted
US Notes No specific FDA cosmetic ban, but limited use; not GRAS; significant toxicity concerns limit practical application

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
moderate
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Toxicological Studies

10 study endpoints found for Potassium Chlorate. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint Value Route Species Study Type Source
NOAEL 100 mg/kg bw/day oral rat oral REACH
NOAEL 100 mg/kg bw/day oral - oral REACH
NOAEL 360 mg/kg bw/day oral dog oral REACH
NOAEL 55 mg/kg bw/day oral rat oral REACH
NOAEL 35 mg/kg bw/day oral rat oral REACH
NOAEL 365 mg/kg bw/day oral mouse oral REACH
NOAEL 360 mg/kg bw/day oral - oral REACH
NOAEL 55 mg/kg bw/day oral - oral REACH
NOAEL 35 mg/kg bw/day oral - oral REACH
NOAEL 365 mg/kg bw/day oral - oral REACH

GHS Hazard Classification

Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.

Signal Word
DANGER
Pictograms
flam circle; excl mark;warn; enviro;aqua
Hazard Statements
May cause fire or explosion; strong oxidizer Harmful if swallowed or if inhaled Causes damage to blood May cause damage to blood through prolonged or repeated exposure Toxic to aquatic life with long lasting effects
Short-term Exposure Effects
The substance is irritating to the respiratory tract. The substance may cause effects on the blood and kidneys. This may result in haemolysis, the formation of methaemoglobin and kidney impairment. The effects may be delayed. Medical observation is indicated.
Long-term Exposure Effects
The substance may have effects on the blood. This may result in the formation of methaemoglobin.
Routes of Exposure
The substance can be absorbed into the body by ingestion and by inhalation of dust.

Expert Verdict

Severe systemic toxicity risk including methemoglobinemia, renal failure, and hemolysis; restricted in EU Annex III; strong oxidizer incompatible with reducing agents; unsuitable for leave-on skin products.

⚠️
Concern Level: High

Frequently Asked Questions

Is Potassium Chlorate safe in cosmetics?

Severe systemic toxicity risk including methemoglobinemia, renal failure, and hemolysis; restricted in EU Annex III; strong oxidizer incompatible with reducing agents; unsuitable for leave-on skin products. The EU classifies Potassium Chlorate as "restricted". Safety rating: POOR. 10 toxicological study endpoint(s) are available in our database.

Is Potassium Chlorate allowed in the EU?

Potassium Chlorate EU regulatory status: restricted. Maximum allowed concentration: 5%. This is based on EU Regulation 1223/2009 and its amendments.

What does Potassium Chlorate do in cosmetics?

Potassium Chlorate functions as: Oxidising agent (historically in oral care products). It is classified as a cosmetic ingredient in our database. CAS number: 3811-04-9.

What is the Margin of Safety for Potassium Chlorate?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

What is the NOAEL for Potassium Chlorate?

The NOAEL (No Observed Adverse Effect Level) for Potassium Chlorate is 100 mg/kg bw/day based on a oral study via oral route in rat. A total of 10 study endpoints are available. Source: REACH.

Is Potassium Chlorate classified as hazardous under GHS?

Potassium Chlorate carries a GHS signal word of "DANGER". Hazard statements: May cause fire or explosion; strong oxidizer Harmful if swallowed or if inhaled Causes damage to blood May cause damage to blood through prolonged or repeated exposure Toxic to aquatic life with long lasting effects. This classification is based on the ILO/WHO International Chemical Safety Card and ECHA C&L inventory data. Note: GHS classification applies to the pure substance — at cosmetic use concentrations, hazard thresholds may not be met.

Compliance Tools

Check Potassium Chlorate compliance across multiple jurisdictions:

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Ingredient Decoder
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82 Allergen Checker
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Substance Compliance
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MoS Calculator
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Heavy Metal Limits
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