Moderate Cosmetic Ingredient

Potato SH-Oligopeptide-2

INCI: POTATO SH-OLIGOPEPTIDE-2

CAS Number
67763-96-6 (base IGF-1 molecule)
Function
Skin conditioning, hair conditioning, anti-wrinkle, collagen and elastin stimulation, fat metabolism modulation
Safety Rating
MODERATE

Regulatory Status

🇪🇺 EU Status permitted
🇺🇸 US Status permitted
US Notes No pre-market approval required; not restricted as cosmetic ingredient

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
negligible
Sensitization
none

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Insulin-like Growth Factor-1 (IGF-1) signaling is linked to cell proliferation pathways with theoretical oncogenicity concern at systemic levels; topical cosmetic doses considered negligible with no CIR monograph available for the potato-expressed form.

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Concern Level: Moderate

Frequently Asked Questions

Is Potato SH-Oligopeptide-2 safe in cosmetics?

Insulin-like Growth Factor-1 (IGF-1) signaling is linked to cell proliferation pathways with theoretical oncogenicity concern at systemic levels; topical cosmetic doses considered negligible with no CIR monograph available for the potato-expressed form. The EU classifies Potato SH-Oligopeptide-2 as "permitted". Safety rating: MODERATE.

Is Potato SH-Oligopeptide-2 allowed in the EU?

Potato SH-Oligopeptide-2 EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Potato SH-Oligopeptide-2 do in cosmetics?

Potato SH-Oligopeptide-2 functions as: Skin conditioning, hair conditioning, anti-wrinkle, collagen and elastin stimulation, fat metabolism modulation. It is classified as a cosmetic ingredient in our database. CAS number: 67763-96-6 (base IGF-1 molecule).

What is the Margin of Safety for Potato SH-Oligopeptide-2?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

Compliance Tools

Check Potato SH-Oligopeptide-2 compliance across multiple jurisdictions:

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Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
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Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
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Heavy Metal Limits
Compare limits across jurisdictions

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