Is PPG-2 Methyl Ether Acetate safe in cosmetics?
PPG-2 Methyl Ether Acetate has a safety rating of "MODERATE" in our database. EU status: permitted. US status: permitted. 1 toxicological study endpoint(s) are available in our database.
PPG-2 Methyl Ether Acetate
Also known as: Propanol, 1(or 2)-(2-methoxymethylethoxy)-, acetate, DPMA (solvent), DPMA acetate, Dowanol DPMA, Arcosolv DPMA (+5 more)
INCI: PPG-2 METHYL ETHER ACETATE
PPG-2 Methyl Ether Acetate (CAS 88917-22-0) is a cosmetic cosmetic ingredient functioning as Solvent; fragrance ingredient. Reported NOAEL =1000 mg/kg bw/day in Rat (ToxValDB_ECHA_IUCLID); EU Regulation 1223/2009 status: permitted; GHS signal word WARNING. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 88917-22-0 →
Auto-generated CPSR Part A draft with source citations
Function
Solvent; fragrance ingredient
Safety Rating
MODERATE
Chemistry & Identifiers
IUPAC Name
1-(1-methoxypropan-2-yloxy)propan-2-yl acetate
InChIKey
LAVARTIQQDZFNT-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Permitted; CIR concluded safe as used at 0.4–2%
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for PPG-2 Methyl Ether Acetate.
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
1 study endpoint found for PPG-2 Methyl Ether Acetate. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =1000 mg/kg bw/day | oral | Rat | short-term | ToxValDB_ECHA_IUCLID |
GHS Hazard Classification
Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.
Signal Word
WARNING
Pictograms
CancerHealth haz
Hazard Statements
Combustible liquid May be fatal if swallowed and enters airways
Short-term Exposure Effects
If swallowed the substance may cause vomiting and could result in aspiration pneumonitis.
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
100 - 1,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (1)
ICSC Safety Card
1752
Source: ILO-WHO International Chemical Safety Cards (ICSCs)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Coalescing agent
Fragrance
Solubility enhancer
Solvent
Regulatory List Membership (3)
IFRA Fragrance Transparency List
EPA Safer Chemical Ingredients List (SCIL)
Consumer Product Chemical
Expert Verdict
Expert safety assessment and concern-level summary for PPG-2 Methyl Ether Acetate.
Regulatory Flags
fragrance-component
epa_safer_alternative
ifra_fragrance
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to PPG-2 Methyl Ether Acetate by CAS number or substance name.
Studies
1
Lowest NOAEL
1000 mg/kg bw/day
Highest NOAEL
1000 mg/kg bw/day
ToxValDB_ECHA_IUCLID
Known Synonyms
Propanol, 1(or 2)-(2-methoxymethylethoxy)-, acetate
DPMA (solvent)
DPMA acetate
Dowanol DPMA
Arcosolv DPMA
Dipropylene glycol monomethyl ether acetate
ACETATE, 1(OR 2)-(2-METHOXYMETHYL-ETHOXY)-, PROPYL
1(or 2)-(2-Methoxymethylethoxy)propanol acetate
EC No.: 618-219-0
UNII-5455FZE9RB
Chemical Function
Solvent
Fragrance
Regulatory Lists
SCIL (9/2019)
IFRA Transparency
consumer_product
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL1255792
Frequently Asked Questions
Is PPG-2 Methyl Ether Acetate allowed in the EU?
PPG-2 Methyl Ether Acetate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does PPG-2 Methyl Ether Acetate do in cosmetics?
PPG-2 Methyl Ether Acetate functions as: Solvent; fragrance ingredient. It is classified as a cosmetic ingredient in our database. CAS number: 88917-22-0.
What is the NOAEL for PPG-2 Methyl Ether Acetate?
The NOAEL (No Observed Adverse Effect Level) for PPG-2 Methyl Ether Acetate is =1000 mg/kg bw/day based on a short-term study via oral route in Rat. Source: ToxValDB_ECHA_IUCLID.
Is PPG-2 Methyl Ether Acetate classified as hazardous under GHS?
PPG-2 Methyl Ether Acetate carries a GHS signal word of "WARNING". Hazard statements: Combustible liquid May be fatal if swallowed and enters airways. This classification is based on the ILO/WHO International Chemical Safety Card and ECHA C&L inventory data. Note: GHS classification applies to the pure substance — at cosmetic use concentrations, hazard thresholds may not be met.
Is PPG-2 Methyl Ether Acetate used outside cosmetics?
PPG-2 Methyl Ether Acetate also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check PPG-2 Methyl Ether Acetate compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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