PPG-33
Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
6 study endpoints found for PPG-33. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 1000 mg/kg bw/day | oral | rat | Subchronic | COSMOS_DB |
| NOAEL | 250 mg/kg bw/day | oral | dog | Subchronic | COSMOS_DB |
| dose_tested | 1000 mg/kg bw/day | oral | rat | Subchronic | COSMOS_DB |
| dose_tested | 250 mg/kg bw/day | oral | dog | Subchronic | COSMOS_DB |
| NOAEL | 1000 mg/kg bw/day | oral | rat | oral | REACH |
| NOAEL | 1000 mg/kg bw/day | oral | code:3544 | oral | REACH |
Expert Verdict
No ethoxylation means no 1,4-dioxane concern; one of the safest PPG variants with minimal expected propylene oxide residuals.
Regulatory Flags
Frequently Asked Questions
Is PPG-33 safe in cosmetics?
No ethoxylation means no 1,4-dioxane concern; one of the safest PPG variants with minimal expected propylene oxide residuals. The EU classifies PPG-33 as "permitted". Safety rating: EXCELLENT. 6 toxicological study endpoint(s) are available in our database.
Is PPG-33 allowed in the EU?
PPG-33 EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does PPG-33 do in cosmetics?
PPG-33 functions as: Skin conditioning, Humectant, Viscosity controlling. It is classified as a cosmetic ingredient in our database. CAS number: 25322-69-4.
What is the Margin of Safety for PPG-33?
adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for PPG-33?
The NOAEL (No Observed Adverse Effect Level) for PPG-33 is 1000 mg/kg bw/day based on a Subchronic study via oral route in rat. A total of 6 study endpoints are available. Source: COSMOS_DB.
Compliance Tools
Check PPG-33 compliance across multiple jurisdictions:
Related Ingredients
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