Good Cosmetic Ingredient Dermal Penetration

Precision Fermentation Ingredients in Cosmetics

INCI: SQUALANE

CAS Number
None
Function
Ferment / Probiotic ingredient
Safety Rating
GOOD

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
EU Max Conc. 0.2%
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes Safe as cosmetic ingredients in the present practices of use and concentration - originally assessed 1982, reaffirmed 2001 and again in the most recent re-review

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
low
Sensitization
none

Calculate MoS for your specific formulation with the MoS Calculator.

Dermal Penetration Profile

Skin absorption and penetration characteristics of Precision Fermentation Ingredients in Cosmetics, relevant to systemic exposure and MoS calculations.

Absorption %
1-4%
Penetration Level
stratum-corneum
Penetration Depth
stratum corneum
Molecular Weight
422.8 Da
Log P
12.8
Systemic Absorption
minimal
Topical Bioavailability
0.5-3%
Safety Margin Factor
low

Source: Cosmetic Science

Expert Verdict

Squalane is generally considered safe for use as a cosmetic ingredient with established safety history.

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Concern Level: Low

Frequently Asked Questions

Is Precision Fermentation Ingredients in Cosmetics safe in cosmetics?

Squalane is generally considered safe for use as a cosmetic ingredient with established safety history. The EU classifies Precision Fermentation Ingredients in Cosmetics as "permitted". Safety rating: GOOD.

Is Precision Fermentation Ingredients in Cosmetics allowed in the EU?

Precision Fermentation Ingredients in Cosmetics EU regulatory status: permitted. Maximum allowed concentration: 0.2%. This is based on EU Regulation 1223/2009 and its amendments.

What does Precision Fermentation Ingredients in Cosmetics do in cosmetics?

Precision Fermentation Ingredients in Cosmetics functions as: Ferment / Probiotic ingredient. It is classified as a Cosmetic Ingredient in our database. CAS number: None.

What is the Margin of Safety for Precision Fermentation Ingredients in Cosmetics?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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