Is Pregnadienol safe in cosmetics?
Pregnadienol has a safety rating of "MODERATE" in our database. EU status: permitted. US status: permitted.
Moderate
Cosmetic Ingredient
Pregnadienol
Also known as: 3-beta-Hydroxy-5-alpha-pregnan-20-one, 5alpha-Pregnan-20-one, 3beta-hydroxy-, Pregnan-20-one, 3-hydroxy-, (3-beta,5-alpha)-, Allopregnanolone, Isopregnanolone
INCI: PREGNADIENOL
Pregnadienol (CAS 516-55-2) is a cosmetic cosmetic ingredient functioning as Fragrance ingredient. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in pharmaceutical data.
View industrial chemical safety profile for CAS 516-55-2 →
Auto-generated CPSR Part A draft with source citations
Function
Fragrance ingredient
Safety Rating
MODERATE
Chemistry & Identifiers
IUPAC Name
1-[(3S,5S,8R,9S,10S,13S,14S,17S)-3-hydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]ethanone
InChIKey
AURFZBICLPNKBZ-FZCSVUEKSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
No specific FDA restriction for cosmetic fragrance use
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Pregnadienol.
Calculate MoS for your specific formulation with the MoS Calculator.
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (1)
Endocrine Disruptors
Potential endocrine disrupting compound
Source: NORMAN Suspect List Exchange
Expert Verdict
Expert safety assessment and concern-level summary for Pregnadienol.
Regulatory Flags
fragrance-component
Known Synonyms
3-beta-Hydroxy-5-alpha-pregnan-20-one
5alpha-Pregnan-20-one, 3beta-hydroxy-
Pregnan-20-one, 3-hydroxy-, (3-beta,5-alpha)-
Allopregnanolone
Isopregnanolone
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
SEPRANOLONE
ChEMBL ID
CHEMBL2057301
Max Phase
2
Frequently Asked Questions
Is Pregnadienol allowed in the EU?
Pregnadienol EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Pregnadienol do in cosmetics?
Pregnadienol functions as: Fragrance ingredient. It is classified as a cosmetic ingredient in our database. CAS number: 516-55-2.
Is Pregnadienol used outside cosmetics?
Pregnadienol also appears in pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Pregnadienol compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
Related Ingredients
2,6-Dimethyl-7-octen-2-ol (Dihydromyrcenol)
Excellent
Same category
Fragrance (perfuming), masking
2-Ethoxy-2,6,6-Trimethyl-9-Methylenebicyclo[3.3.1]Nonane (Boisiris™)
Excellent
Same category
Fragrance (rich woody, orris/iris roo...
3,6-Dimethyl-3-Octyl Acetate
Excellent
Same category
Fragrance / Perfuming agent with flor...
3-Methyl-5-(2,2,3-Trimethyl-3-Cyclopentenyl)Pent-4-En-2-Ol (Sandalore)
Excellent
Same category
Perfuming / Fragrance (sandalwood note)
4-Tert-Butylcyclohexyl Acetate
Excellent
Same category
Fragrance
Acetoin
Excellent
Same category
Skin conditioning, fragrance
(20S)-Protopanaxadiol
Moderate
Similar safety
(Cnidium Officinale/Coptis Chinensis/Glycyrrhiza Uralensis) Root Extract
Moderate
Similar safety
Skin conditioning
(Cryptomeria Japonica/Chamaecyparis Obtusa) Stem Ferment Extract
Moderate
Similar safety
Antimicrobial, antioxidant, humectant
(Eclipta Prostrata/Houttuynia Cordata) Leaf Extract
Moderate
Similar safety
Skin conditioning
(Lepidium Meyenii/Sarcodon Aspratus) Root Water
Moderate
Similar safety
Skin conditioning
(Licorice/Reynoutria Japonica) Root/Stem Extract
Moderate
Similar safety
Skin conditioning, antioxidant
PRIMULA VERIS FLOWER EXTRACT
Good
Browse nearby
Skin Conditioning
PROPOLIS WAX
Good
Browse nearby
Skin Conditioning, Skin Conditioning ...
PROPYL TRIMETHICONE METHACRYLATE CROSSPOLYMER
Good
Browse nearby
Film forming, skin conditioning, text...
Is Pregnadienol in Your Products?
Scan any product label with Piro — our free ingredient scanner. Point your camera at the ingredients list and get instant safety scores for every ingredient.
Try Piro Free →Analyze Your Full Ingredient List
Paste any INCI list into the Decoder for instant safety analysis, or calculate the Margin of Safety for Pregnadienol in your formulation.