Propanediol Diisostearate

INCI: PROPANEDIOL DIISOSTEARATE

CAS Number
Not assigned / not publicly reported
Function
Skin Conditioning — Emollient
Safety Rating
MODERATE

Regulatory Status

🇪🇺 EU Status permitted
🇺🇸 US Status permitted
US Notes Not restricted; not reported in FDA VCRP as of 2017 CIR review

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
negligible
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

No CAS number publicly confirmed. CIR data profile shows zero data across all endpoints — no ADME, acute tox, repeated dose, irritation, sensitization, genotox, or repro data . Read-across from Neopentyl Glycol Diisostearate may partially support safety but formal assessment is incomplete.

⚠️
Concern Level: Moderate

Regulatory Flags

potential-allergen

Frequently Asked Questions

Is Propanediol Diisostearate safe in cosmetics?

No CAS number publicly confirmed. CIR data profile shows zero data across all endpoints — no ADME, acute tox, repeated dose, irritation, sensitization, genotox, or repro data . Read-across from Neopentyl Glycol Diisostearate may partially support safety but formal assessment is incomplete. The EU classifies Propanediol Diisostearate as "permitted". Safety rating: MODERATE.

Is Propanediol Diisostearate allowed in the EU?

Propanediol Diisostearate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Propanediol Diisostearate do in cosmetics?

Propanediol Diisostearate functions as: Skin Conditioning — Emollient. It is classified as a cosmetic ingredient in our database. CAS number: Not assigned / not publicly reported.

What is the Margin of Safety for Propanediol Diisostearate?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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