Propionibacterium Acnes/Propionibacterium Granulosum Extract

INCI: PROPIONIBACTERIUM ACNES/PROPIONIBACTERIUM GRANULOSUM EXTRACT

CAS Number
No single CAS; biotechnology-derived extract
Function
Skin conditioning; microbiome-balancing; probiotic-derived bioactive
Safety Rating
MODERATE

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes Permitted; no specific restrictions. However, probiotic-derived claims may attract FDA scrutiny under drug vs. cosmetic classification

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
low
Sensitization
moderate

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Major flag: Source organisms are commensal skin bacteria associated with acne. Must ensure extract is fully inactivated with no viable organisms. Regulatory grey area between cosmetic and biologic/drug. Needs robust safety dossier for EU CPSR

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Concern Level: Moderate

Regulatory Flags

plant-extract

Frequently Asked Questions

Is Propionibacterium Acnes/Propionibacterium Granulosum Extract safe in cosmetics?

Major flag: Source organisms are commensal skin bacteria associated with acne. Must ensure extract is fully inactivated with no viable organisms. Regulatory grey area between cosmetic and biologic/drug. Needs robust safety dossier for EU CPSR The EU classifies Propionibacterium Acnes/Propionibacterium Granulosum Extract as "permitted". Safety rating: MODERATE.

Is Propionibacterium Acnes/Propionibacterium Granulosum Extract allowed in the EU?

Propionibacterium Acnes/Propionibacterium Granulosum Extract EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Propionibacterium Acnes/Propionibacterium Granulosum Extract do in cosmetics?

Propionibacterium Acnes/Propionibacterium Granulosum Extract functions as: Skin conditioning; microbiome-balancing; probiotic-derived bioactive. It is classified as a cosmetic ingredient in our database. CAS number: No single CAS; biotechnology-derived extract.

What is the Margin of Safety for Propionibacterium Acnes/Propionibacterium Granulosum Extract?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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