Regulatory Status
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Safety Data
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Dermal Penetration Profile
Skin absorption and penetration characteristics of Retinyl Retinoate, relevant to systemic exposure and MoS calculations.
Source: J Cosmet Dermatol 2017
Expert Verdict
Novel hybrid retinoid with promising small-scale RCT data showing 0.06% retinyl retinoate cream outperformed 0.075% retinol cream for wrinkle depth, wrinkle area, and visual improvement with maximum roughness improvement 22% higher than retinol after 12 weeks. Designed to combine photostability of retinyl esters with retinoid receptor activity. Evidence base is limited to one small RCT (n=11), which constrains confidence. Not currently subject to EU vitamin A Annex III caps.
Regulatory Flags
Frequently Asked Questions
Is Retinyl Retinoate safe in cosmetics?
Novel hybrid retinoid with promising small-scale RCT data showing 0.06% retinyl retinoate cream outperformed 0.075% retinol cream for wrinkle depth, wrinkle area, and visual improvement with maximum roughness improvement 22% higher than retinol after 12 weeks. Designed to combine photostability of retinyl esters with retinoid receptor activity. Evidence base is limited to one small RCT (n=11), which constrains confidence. Not currently subject to EU vitamin A Annex III caps. The EU classifies Retinyl Retinoate as "permitted". Safety rating: GOOD.
Is Retinyl Retinoate allowed in the EU?
Retinyl Retinoate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Retinyl Retinoate do in cosmetics?
Retinyl Retinoate functions as: Hybrid vitamin A derivative combining retinol and retinoic acid moieties in a single ester; promotes wrinkle reduction and skin renewal. It is classified as a Active Ingredient in our database. CAS number: 15498-86-9.
What is the Margin of Safety for Retinyl Retinoate?
adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
Compliance Tools
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Related Ingredients
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