Good Active Ingredient

Capixyl

INCI: ACETYL TETRAPEPTIDE-3 (AND) TRIFOLIUM PRATENSE FLOWER EXTRACT

Function
hair-growth active; ECM protein synthesis stimulant; 5-alpha-reductase inhibitor; anti-inflammatory; follicle structure strengthener
Safety Rating
GOOD

Regulatory Status

🇪🇺 EU Status permitted
EU Max Conc. 5%
🇺🇸 US Status permitted
US Notes FDA does not recognize Capixyl as a drug; marketed only as cosmetic. Products must avoid hair regrowth or hair loss prevention claims which trigger drug classification. Only minoxidil (2%/5%) is FDA-approved OTC for androgenetic alopecia.

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
low
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Capixyl is a proprietary complex combining Acetyl Tetrapeptide-3 and Trifolium Pratense Flower Extract, permitted under EU Regulation 1223/2009 with no Annex II/III restrictions and classified as a cosmetic ingredient by the FDA, though hair-growth claims require careful positioning to avoid drug classification.

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Concern Level: Low

Regulatory Flags

no-sccs-opinion no-cir-review isoflavone-endocrine-flag us-drug-claim-risk manufacturer-data-only peptide-over-500da

Frequently Asked Questions

Is Capixyl safe in cosmetics?

Capixyl is a proprietary complex combining Acetyl Tetrapeptide-3 and Trifolium Pratense Flower Extract, permitted under EU Regulation 1223/2009 with no Annex II/III restrictions and classified as a cosmetic ingredient by the FDA, though hair-growth claims require careful positioning to avoid drug classification. The EU classifies Capixyl as "permitted". Safety rating: GOOD.

Is Capixyl allowed in the EU?

Capixyl EU regulatory status: permitted. Maximum allowed concentration: 5%. This is based on EU Regulation 1223/2009 and its amendments.

What does Capixyl do in cosmetics?

Capixyl functions as: hair-growth active; ECM protein synthesis stimulant; 5-alpha-reductase inhibitor; anti-inflammatory; follicle structure strengthener. It is classified as a Active Ingredient in our database.

What is the Margin of Safety for Capixyl?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

Compliance Tools

Check Capixyl compliance across multiple jurisdictions:

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Ingredient Decoder
Paste a full ingredient list for instant analysis
 🌸
82 Allergen Checker
Check for EU declarable fragrance allergens
 🧪
Substance Compliance
Check compliance across 55 jurisdictions
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
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Heavy Metal Limits
Compare limits across jurisdictions

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