Good Antioxidant NOAEL Data

Rosemary Extract

INCI: ROSMARINUS OFFICINALIS LEAF EXTRACT

CAS Number

84604-14-8

Function

antioxidant, preservative booster, antimicrobial

Safety Rating

GOOD

Regulatory Status

🇪🇺 EU Status permitted

🇺🇸 US Status permitted

US Notes GRAS status confirmed under 21 CFR 182.10 (spice/flavoring) and 21 CFR 182.20 (essential oil/natural extractive). CIR Expert Panel (2018) concluded safe as used when formulated to be non-sensitizing, with <=0.2% as the tested safe leave-on concentration.

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)

not established

Dermal Absorption

moderate

Sensitization

low

Calculate MoS for your specific formulation with the MoS Calculator.

Toxicological Studies

8 study endpoints found for Rosemary Extract. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint	Value	Route	Species	Study Type	Source
NOAEL	200 mg/kg bw/day	oral	rat	Short Term Toxicity	COSMOS_DB
NOAEL	130 mg/kg bw/day	oral	rat	Developmental	COSMOS_DB
NOAEL	130 mg/kg bw/day	oral	rat	Developmental	COSMOS_DB
NOAEL	1500 mg/kg bw/day	oral	rat	Short Term Toxicity	COSMOS_DB
dose_tested	200 mg/kg bw/day	oral	rat	Short Term Toxicity	COSMOS_DB
dose_tested	130 mg/kg bw/day	oral	rat	Developmental	COSMOS_DB
dose_tested	130 mg/kg bw/day	oral	rat	Developmental	COSMOS_DB
dose_tested	1500 mg/kg bw/day	oral	rat	Short Term Toxicity	COSMOS_DB

Expert Verdict

CAS 84604-14-8 (EINECS 283-291-9). EU: Permitted under Regulation (EC) 1223/2009; not listed in any restrictive Annex. Contains fragrance allergens linalool and limonene requiring label declaration above thresholds. US: GRAS under 21 CFR 182.10, 182.20, 582.10. CIR 2018 concluded safe as used when formulated to be non-sensitizing at <=0.2% leave-on.

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Concern Level: Low

Regulatory Flags

fragrance-allergen contact-dermatitis-risk eu-allergen-labeling-required botanical eu_children_restricted fda_food_additive

Frequently Asked Questions

Is Rosemary Extract safe in cosmetics?

Is Rosemary Extract allowed in the EU?

Rosemary Extract EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Rosemary Extract do in cosmetics?

Rosemary Extract functions as: antioxidant, preservative booster, antimicrobial. It is classified as a Antioxidant in our database. CAS number: 84604-14-8.

What is the Margin of Safety for Rosemary Extract?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

What is the NOAEL for Rosemary Extract?

The NOAEL (No Observed Adverse Effect Level) for Rosemary Extract is 200 mg/kg bw/day based on a Short Term Toxicity study via oral route in rat. A total of 8 study endpoints are available. Source: COSMOS_DB.

Compliance Tools

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82 Allergen Checker

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Substance Compliance

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MoS Calculator

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Heavy Metal Limits

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