Is Rutin safe in cosmetics?
Rutin has a safety rating of "EXCELLENT" in our database. EU status: permitted. US status: permitted.
Excellent
Cosmetic Ingredient
Rutin
INCI: RUTIN
Rutin (CAS 153-18-4 / 130603-71-4) is a cosmetic cosmetic ingredient functioning as Antioxidant, Skin Conditioning, Skin Protecting, Smoothing, Soothing. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database.
View industrial chemical safety profile for CAS 153-18-4 / 130603-71-4 →
Auto-generated CPSR Part A draft with source citations
Function
Antioxidant, Skin Conditioning, Skin Protecting, Smoothing, Soothing
Safety Rating
EXCELLENT
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Generally recognized as safe; widely used in cosmetics and dietary supplements
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Rutin.
Calculate MoS for your specific formulation with the MoS Calculator.
Additional Ingredient Properties
7 property records from structured ingredient metadata.
acne
{"cas_number": "153-18-4", "anti_acne_mechanism": "anti_inflammatory", "comedogenicity_rating_0_to_5": "0", "acne_type_efficacy": "inflammatory", "sebum_reduction_pct_clinical": "0-10", "prescription_required_usa": "No", "otc_drug_monograph_category": "No", "max_otc_concentration_pct": "No limit", "japan_quasi_drug_anti_acne": "No", "korea_functional_cosmetic_acne": "No", "eu_cosmetic_restriction_…
anti_aging
{"anti_aging_claim": "antioxidant-protection, barrier-repair", "mechanism_of_action": "Bioactive compound, specialized mechanism", "target_skin_layer": "epidermis, dermis", "collagen_stimulation": "Mild", "elastin_protection": "Mild", "wrinkle_reduction_pct": "8-15", "clinical_study_duration_weeks": "12", "sample_size": "35", "double_blind": "No", "placebo_controlled": "Yes", "published_journal": …
anti_pollution
{"cas_number": "153-18-4", "ingredient_class": "antioxidant_pollution_shield", "primary_mechanism": "free_radical_scavenging", "pollution_types_targeted": "PM2_5", "IR_A_protection": "no", "visible_light_protection": "no", "digital_screen_protection_claim": "no", "PAH_neutralization": "no", "ozone_protection": "no", "mitochondrial_protection": "no", "Nrf2_activation": "no", "AhR_pathway_modulation…
antioxidant
{"cas_number": "153-18-4", "antioxidant_class": "flavonoid", "chemical_subclass": "quercetin glycoside", "molecular_weight_daltons": "610.52", "orac_value_umol_te_per_g": "11200", "dpph_radical_scavenging_ic50_ug_per_ml": "15-25", "abts_trolox_equivalent": "1.0", "singlet_oxygen_quenching": "high", "superoxide_dismutase_mimetic": "moderate", "hydroxyl_radical_scavenging": "high", "lipid_peroxidati…
depigmentation
{"cas_number": "153-18-4", "ingredient_class": "combined_mechanism", "primary_mechanism_of_action": "Quercetin glycoside with antioxidant and anti-inflammatory effects", "secondary_mechanisms": "Variable", "molecular_target": "other", "tyrosinase_inhibition_IC50_uM": "varies", "tyrosinase_inhibition_type": "competitive", "melanin_reduction_pct_in_vitro": "25-45", "melanin_reduction_pct_clinical": …
pregnancy_detail
{"pregnancy_safe": "yes", "breastfeeding_safe": "yes", "risk_category": "not-rated", "reason": "Safe; bioflavonoid antioxidant", "source": "dermatology literature"}
skin_suitability
{"oily_skin": "acceptable", "dry_skin": "acceptable", "sensitive_skin": "acceptable", "combination_skin": "acceptable", "normal_skin": "acceptable", "acne_prone": "acceptable", "rosacea": "recommended", "eczema": "acceptable", "hyperpigmentation": "acceptable", "aging_mature": "acceptable", "dehydrated": "acceptable", "skin_benefit_primary": "antioxidant", "skin_benefit_secondary": "capillary-stre…
Expert Verdict
Expert safety assessment and concern-level summary for Rutin.
Regulatory Flags
natural-origin
fda_food_additive
Frequently Asked Questions
Is Rutin allowed in the EU?
Rutin EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Rutin do in cosmetics?
Rutin functions as: Antioxidant, Skin Conditioning, Skin Protecting, Smoothing, Soothing. It is classified as a cosmetic ingredient in our database. CAS number: 153-18-4 / 130603-71-4.
Compliance Tools
Check Rutin compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
Related Ingredients
2-O-Ethyl Ascorbic Acid
Excellent
Same category
Softener and conditioner
3-Glyceryl Ascorbate
Excellent
Same category
Antioxidant, Humectant, Skin Conditio...
Allantoin Ascorbate
Excellent
Same category
Antioxidant, Skin Conditioning, Skin ...
Aloe Vera Extract
Excellent
Same category
Skin Conditioning, Antioxidant
Althaea Officinalis Callus Culture Extract
Excellent
Same category
Antioxidant, skin protectant
Amaranthus Caudatus Seed Oil
Excellent
Same category
Emollient, skin conditioning, antioxi...
1-Methylhydantoin-2-imide (Creatinine)
Excellent
Similar safety
Skin conditioning (skin brightening/l...
2,6-Dimethyl-7-octen-2-ol (Dihydromyrcenol)
Excellent
Similar safety
Fragrance (perfuming), masking
2-Ethoxy-2,6,6-Trimethyl-9-Methylenebicyclo[3.3.1]Nonane (Boisiris™)
Excellent
Similar safety
Fragrance (rich woody, orris/iris roo...
2-Hydroxypropylcarbamato Amodimethicone
Excellent
Similar safety
Hair conditioning; modified aminosili...
3 O Ethyl Ascorbic Acid
Excellent
Similar safety
Antioxidant; tyrosinase inhibitor; me...
3,6-Dimethyl-3-Octyl Acetate
Excellent
Similar safety
Fragrance / Perfuming agent with flor...
Rabbit Fat
Good
Browse nearby
Skin conditioning
Rabdosia Rubescens Extract
Good
Browse nearby
Skin conditioning
Radish Root Ferment Filtrate
Good
Browse nearby
Skin conditioning, antimicrobial, nat...
Is Rutin in Your Products?
Scan any product label with Piro — our free ingredient scanner. Point your camera at the ingredients list and get instant safety scores for every ingredient.
Try Piro Free →Analyze Your Full Ingredient List
Paste any INCI list into the Decoder for instant safety analysis, or calculate the Margin of Safety for Rutin in your formulation.