Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
3 study endpoints found for Salicylamide. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 200 mg/kg bw/day | oral | rat | oral | REACH |
| NOEL | >=250 mg/kg bw/day | oral | mouse | oral | REACH |
| NOAEL | 1000 mg/kg bw/day | oral | mouse | oral | REACH |
Expert Verdict
Primarily a pharmaceutical ingredient; limited cosmetic safety data; salicylate cross-reactivity risk; not to be used in children's products without assessment; inhibits prostaglandin synthesis
Regulatory Flags
Frequently Asked Questions
Is Salicylamide safe in cosmetics?
Primarily a pharmaceutical ingredient; limited cosmetic safety data; salicylate cross-reactivity risk; not to be used in children's products without assessment; inhibits prostaglandin synthesis The EU classifies Salicylamide as "permitted". Safety rating: MODERATE. 3 toxicological study endpoint(s) are available in our database.
Is Salicylamide allowed in the EU?
Salicylamide EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Salicylamide do in cosmetics?
Salicylamide functions as: Antimicrobial / Preservative agent in cosmetics; also pharmaceutical analgesic/antipyretic. It is classified as a cosmetic ingredient in our database. CAS number: 65-45-2.
What is the Margin of Safety for Salicylamide?
adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Salicylamide?
The NOAEL (No Observed Adverse Effect Level) for Salicylamide is 200 mg/kg bw/day based on a oral study via oral route in rat. A total of 3 study endpoints are available. Source: REACH.
Compliance Tools
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Related Ingredients
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