Moderate Cosmetic Ingredient

SH-Pentapeptide-12 SP

INCI: SH-PENTAPEPTIDE-12 SP

CAS Number
Not publicly assigned
Function
Skin conditioning ; described as a Type C botulinum toxin-mimetic peptide (neurotransmitter-inhibitor class)
Safety Rating
MODERATE

Regulatory Status

🇪🇺 EU Status permitted
🇺🇸 US Status permitted
US Notes No FDA monograph; MoCRA self-assessment applies

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
low
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

🔴 Botulinum toxin-mimetic claim (SpecPed® Sh-PP12 product literature) demands full toxicological dossier including systemic toxicity, neurotoxicity evaluation, and justified MoS. The gap between the marketing claim and the available safety data is concerning

⚠️
Concern Level: High

Frequently Asked Questions

Is SH-Pentapeptide-12 SP safe in cosmetics?

🔴 Botulinum toxin-mimetic claim (SpecPed® Sh-PP12 product literature) demands full toxicological dossier including systemic toxicity, neurotoxicity evaluation, and justified MoS. The gap between the marketing claim and the available safety data is concerning The EU classifies SH-Pentapeptide-12 SP as "permitted". Safety rating: MODERATE.

Is SH-Pentapeptide-12 SP allowed in the EU?

SH-Pentapeptide-12 SP EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does SH-Pentapeptide-12 SP do in cosmetics?

SH-Pentapeptide-12 SP functions as: Skin conditioning ; described as a Type C botulinum toxin-mimetic peptide (neurotransmitter-inhibitor class). It is classified as a cosmetic ingredient in our database. CAS number: Not publicly assigned.

What is the Margin of Safety for SH-Pentapeptide-12 SP?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

Compliance Tools

Check SH-Pentapeptide-12 SP compliance across multiple jurisdictions:

🔬
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
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Substance Compliance
Check compliance across 55 jurisdictions
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
 ⚗️
Heavy Metal Limits
Compare limits across jurisdictions

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