sh-Polypeptide-111

INCI: SH-POLYPEPTIDE-111

CAS Number
Not publicly assigned
Function
Skin conditioning; appears in fusion protein complexes targeting IgE/IL-10 receptors (anti-inflammatory/immune modulation context)
Safety Rating
MODERATE

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes No specific restriction; general cosmetic ingredient

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
negligible
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Used as a component in fusion protein dimers (CHO-expressed); IgE-binding peptide component โ€” flag for regulatory review if making any anti-inflammatory claims; no standalone safety dossier

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Concern Level: Moderate

Frequently Asked Questions

Is sh-Polypeptide-111 safe in cosmetics?

Used as a component in fusion protein dimers (CHO-expressed); IgE-binding peptide component โ€” flag for regulatory review if making any anti-inflammatory claims; no standalone safety dossier The EU classifies sh-Polypeptide-111 as "permitted". Safety rating: MODERATE.

Is sh-Polypeptide-111 allowed in the EU?

sh-Polypeptide-111 EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does sh-Polypeptide-111 do in cosmetics?

sh-Polypeptide-111 functions as: Skin conditioning; appears in fusion protein complexes targeting IgE/IL-10 receptors (anti-inflammatory/immune modulation context). It is classified as a cosmetic ingredient in our database. CAS number: Not publicly assigned.

What is the Margin of Safety for sh-Polypeptide-111?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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