Moderate Cosmetic Ingredient

SH-Polypeptide-46

INCI: SH-POLYPEPTIDE-46

CAS Number
Not assigned / not publicly available
Function
Skin Conditioning
Safety Rating
MODERATE

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes INCI registered; no FDA pre-market approval required

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
negligible
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

๐Ÿ”ด IFN-ฮฑ2 is a potent cytokine โ€” pharmaceutical-grade interferons are prescription drugs (e.g., Roferon-A). Even at cosmetic trace levels, the use of a recombinant interferon in cosmetics is biologically significant and raises questions about pharmacological activity vs. cosmetic claim boundaries

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Concern Level: Moderate

Frequently Asked Questions

Is SH-Polypeptide-46 safe in cosmetics?

๐Ÿ”ด IFN-ฮฑ2 is a potent cytokine โ€” pharmaceutical-grade interferons are prescription drugs (e.g., Roferon-A). Even at cosmetic trace levels, the use of a recombinant interferon in cosmetics is biologically significant and raises questions about pharmacological activity vs. cosmetic claim boundaries The EU classifies SH-Polypeptide-46 as "permitted". Safety rating: MODERATE.

Is SH-Polypeptide-46 allowed in the EU?

SH-Polypeptide-46 EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does SH-Polypeptide-46 do in cosmetics?

SH-Polypeptide-46 functions as: Skin Conditioning. It is classified as a cosmetic ingredient in our database. CAS number: Not assigned / not publicly available.

What is the Margin of Safety for SH-Polypeptide-46?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

Compliance Tools

Check SH-Polypeptide-46 compliance across multiple jurisdictions:

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Ingredient Decoder
Paste a full ingredient list for instant analysis
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82 Allergen Checker
Check for EU declarable fragrance allergens
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Substance Compliance
Check compliance across 55 jurisdictions
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
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Heavy Metal Limits
Compare limits across jurisdictions

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