Silkworm sh-Oligopeptide-1

INCI: SILKWORM SH-OLIGOPEPTIDE-1

CAS Number
1807528-51-3 (for sh-Oligopeptide-1 / EGF)
Function
Skin Conditioning (EGF — Epidermal Growth Factor analog; promotes cell proliferation, wound healing, anti-aging)
Safety Rating
MODERATE

Regulatory Status

🇪🇺 EU Status permitted
🇺🇸 US Status permitted
US Notes Not specifically restricted; growth factor peptides are under scrutiny but not banned for cosmetic use

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
low
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Growth factor ingredient — stimulates cell proliferation ; theoretical concern re: promotion of abnormal cell growth with long-term use; not recommended on damaged/compromised skin; GMO-derived; some jurisdictions may classify growth factor products differently

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Concern Level: Moderate

Frequently Asked Questions

Is Silkworm sh-Oligopeptide-1 safe in cosmetics?

Growth factor ingredient — stimulates cell proliferation ; theoretical concern re: promotion of abnormal cell growth with long-term use; not recommended on damaged/compromised skin; GMO-derived; some jurisdictions may classify growth factor products differently The EU classifies Silkworm sh-Oligopeptide-1 as "permitted". Safety rating: MODERATE.

Is Silkworm sh-Oligopeptide-1 allowed in the EU?

Silkworm sh-Oligopeptide-1 EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Silkworm sh-Oligopeptide-1 do in cosmetics?

Silkworm sh-Oligopeptide-1 functions as: Skin Conditioning (EGF — Epidermal Growth Factor analog; promotes cell proliferation, wound healing, anti-aging). It is classified as a cosmetic ingredient in our database. CAS number: 1807528-51-3 (for sh-Oligopeptide-1 / EGF).

What is the Margin of Safety for Silkworm sh-Oligopeptide-1?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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