Is SILYBUM MARIANUM EXTRACT safe in cosmetics?
SILYBUM MARIANUM EXTRACT has a safety rating of "GOOD" in our database. EU status: permitted.
Good
Cosmetic Ingredient
SILYBUM MARIANUM EXTRACT
Also known as: Silybum marianum extracts, Flavopherol, EINECS 283-298-7, Lady's thistle (Silybum marianum L. Gaertner), Milk thistle extracts
SILYBUM MARIANUM EXTRACT (CAS 84604-20-6) is a cosmetic cosmetic ingredient functioning as Skin Conditioning. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety, pharmaceutical, and food safety data.
View industrial chemical safety profile for CAS 84604-20-6 →
Auto-generated CPSR Part A draft with source citations
Function
Skin Conditioning
Safety Rating
GOOD
Regulatory Status
EU EU Status
permitted
US US Status
Not specifically regulated
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
1 - 10 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Additional Ingredient Properties
1 property record from structured ingredient metadata.
anti_aging
{"anti_aging_claim": "antioxidant-protection, brightening", "mechanism_of_action": "Silymarin, flavonolignans", "target_skin_layer": "epidermis", "collagen_stimulation": "No", "elastin_protection": "Mild", "wrinkle_reduction_pct": "6-12", "clinical_study_duration_weeks": "8", "sample_size": "30", "double_blind": "No", "placebo_controlled": "Yes", "published_journal": "Phytotherapy Research, JOCD",…
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Humectant
Softener and conditioner
Expert Verdict
Expert safety assessment and concern-level summary for SILYBUM MARIANUM EXTRACT.
Regulatory Flags
cosing-sourced
eu-permitted
skin-conditioning
needs-enrichment
Known Synonyms
Silybum marianum extracts
Flavopherol
EINECS 283-298-7
Lady's thistle (Silybum marianum L. Gaertner)
Milk thistle extracts
Chemical Function
Softener and conditioner
Humectant
Regulatory Lists
Canada; Personal care; Substances in PCP - Canada (4/2014)
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical and food safety data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA count match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Adverse Event Associations
582
SOURCE
EFSA / FDA GRAS
food_additives
Food Safety Data
Same-CAS food additive or FDA GRAS records from the core public database.
Food Name
Milk thistle extract
Food Category
preservative
Frequently Asked Questions
Is SILYBUM MARIANUM EXTRACT allowed in the EU?
SILYBUM MARIANUM EXTRACT EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does SILYBUM MARIANUM EXTRACT do in cosmetics?
SILYBUM MARIANUM EXTRACT functions as: Skin Conditioning. It is classified as a cosmetic ingredient in our database. CAS number: 84604-20-6.
Is SILYBUM MARIANUM EXTRACT used outside cosmetics?
SILYBUM MARIANUM EXTRACT also appears in industrial chemical safety, pharmaceutical, and food safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check SILYBUM MARIANUM EXTRACT compliance across multiple jurisdictions:
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Substance Compliance
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MoS Calculator
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Heavy Metal Limits
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