Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
4 study endpoints found for Silver Oxide. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 30 mg/kg bw/day | oral | rat | oral | REACH |
| NOAEL | 1.5 mg/kg bw/day | other | rat | oral | REACH |
| NOAEL | 30 mg/kg bw/day | oral | rat | oral | REACH |
| NOAEL | 1.5 mg/kg bw/day | other | rat | oral | REACH |
Expert Verdict
Silver CMR Cat 2 classification; potential for argyria with chronic exposure; EU regulatory landscape for all silver compounds is tightening significantly
Frequently Asked Questions
Is Silver Oxide safe in cosmetics?
Silver CMR Cat 2 classification; potential for argyria with chronic exposure; EU regulatory landscape for all silver compounds is tightening significantly The EU classifies Silver Oxide as "prohibited". Safety rating: MODERATE. 4 toxicological study endpoint(s) are available in our database.
Is Silver Oxide allowed in the EU?
Silver Oxide EU regulatory status: prohibited. Maximum allowed concentration: 0.2%. This is based on EU Regulation 1223/2009 and its amendments.
What does Silver Oxide do in cosmetics?
Silver Oxide functions as: Antimicrobial agent. It is classified as a cosmetic ingredient in our database. CAS number: 20667-12-3.
What is the Margin of Safety for Silver Oxide?
not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Silver Oxide?
The NOAEL (No Observed Adverse Effect Level) for Silver Oxide is 30 mg/kg bw/day based on a oral study via oral route in rat. A total of 4 study endpoints are available. Source: REACH.
Compliance Tools
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Related Ingredients
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