Is Silver Oxide safe in cosmetics?
Silver Oxide has a safety rating of "MODERATE" in our database. EU status: prohibited. US status: restricted.
Moderate
Cosmetic Ingredient
Silver Oxide
Also known as: Argentous oxide, Disilver monoxide, Disilver oxide, Silver(I) oxide, EINECS No.: 243-957-1
INCI: SILVER OXIDE
Silver Oxide (CAS 20667-12-3) is a cosmetic cosmetic ingredient functioning as Antimicrobial agent. NOAEL 30 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: prohibited, max 0.2%. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 20667-12-3 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
Silver Oxide is prohibited in EU cosmetics at max 0.2% but has active industrial GHS classifications (H271, H272, H318, H400, H410).
Source: Cosmetics: ingredients.eu_status/eu_max; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
Antimicrobial agent
Safety Rating
MODERATE
Regulatory Status
EU EU Status
prohibited
EU Max Conc.
0.2%
US US Status
restricted
US Notes
Not specifically restricted in cosmetics; no FDA colorant listing
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Silver Oxide.
Calculate MoS for your specific formulation with the MoS Calculator.
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for Silver Oxide across SCCS product categories, with measured dermal absorption where available.
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
100 - 1,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Additional Ingredient Properties
1 property record from structured ingredient metadata.
anti_aging
{"anti_aging_claim": "antimicrobial, anti-inflammatory", "mechanism_of_action": "Cofactor for enzymatic reactions, ionic balance", "target_skin_layer": "epidermis", "collagen_stimulation": "No", "elastin_protection": "No", "wrinkle_reduction_pct": "5-10", "clinical_study_duration_weeks": "8", "sample_size": "20", "double_blind": "No", "placebo_controlled": "Yes", "published_journal": "Trace elemen…
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Biocide
Surface modifier
Expert Verdict
Expert safety assessment and concern-level summary for Silver Oxide.
Known Synonyms
Argentous oxide
Disilver monoxide
Disilver oxide
Silver(I) oxide
EINECS No.: 243-957-1
Chemical Function
Biocide
Surface modifier
Regulatory Lists
active_ingredient; Europe; Pesticides
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA count match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Adverse Event Associations
22
Frequently Asked Questions
Is Silver Oxide allowed in the EU?
Silver Oxide EU regulatory status: prohibited. Maximum allowed concentration: 0.2%. This is based on EU Regulation 1223/2009 and its amendments.
What does Silver Oxide do in cosmetics?
Silver Oxide functions as: Antimicrobial agent. It is classified as a cosmetic ingredient in our database. CAS number: 20667-12-3.
Is Silver Oxide used outside cosmetics?
Silver Oxide also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does Silver Oxide have different safety status in cosmetics vs industrial chemicals?
Silver Oxide is prohibited in EU cosmetics at max 0.2% but has active industrial GHS classifications (H271, H272, H318, H400, H410).
Compliance Tools
Check Silver Oxide compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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