MODERATE Cosmetic Ingredient

Sodium Bisulfate

Also known as: Caswell No. 742, EINECS 231-665-7, EPA Pesticide Chemical Code 073201, NSC 71192, Sodium bisulfate, fused (+5 more)

INCI: SODIUM BISULFATE

Sodium Bisulfate (CAS 7681-38-1) is a cosmetic cosmetic ingredient functioning as pH adjuster; buffering agent. NOAEL 2000 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: restricted, max 0.2%. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety, pharmaceutical, and food safety data.

View industrial chemical safety profile for CAS 7681-38-1 →

CAS Number
7681-38-1
View industrial chemical safety profile →
Function
pH adjuster; buffering agent
Editorial assessment
MODERATE
Preliminary editorial note — not a computed safety verdict.

Chemistry & Identifiers

Formula
HNaO4S
MW
120.06 g/mol
EC Number
231-665-7
PubChem CID
516919
IUPAC Name
sodium hydrogen sulfate
InChIKey
WBHQBSYUUJJSRZ-UHFFFAOYSA-M
UNII: BU8V88OWIQ Wikidata: Q411103

Regulatory Status

EU EU Status restricted
EU Max Conc. 0.2%
US US Status permitted
US Notes GRAS (Generally Recognized as Safe) for food contact; permitted in cosmetics as pH adjuster; no specific FDA restriction for cosmetic use

For full compliance data across multiple jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety, dermal absorption, and sensitization profile summaries for Sodium Bisulfate.

Calculate MoS for your specific formulation with the MoS Calculator.

Pre-Calculated Safety Assessment

Pre-calculated NOAEL → SED → MoS audit trail for Sodium Bisulfate across SCCS product categories, with measured dermal absorption where available.

EU CLP Annex VI Harmonized Classification

Legally binding harmonized classification per Regulation (EC) No 1272/2008 (CLP) Annex VI.

Signal Word
Danger
Pictograms
Corrosive
Hazard Class and Category
Eye Dam. 1
Hazard Statements
  • H318 Causes serious eye damage

Inserted via ATP: CLP00

ECHA REACH Registration

European Chemicals Agency REACH dossier and Substances of Very High Concern listing.

Registration Type
Full
Tonnage Band
10,000 - 100,000 tonnes
Substance Type
GROUP; SUBSTANCE
SVHC Candidate
No
Hazard classification: Restricted (Annex XVII)

PubChem Annotations

Safety and regulatory annotations from PubChem (NCBI) aggregated sources.

Regulatory (2)
JECFA Evaluation
SODIUM HYDROGEN SULFATE | 2009 | NOT SPECIFIED | TRS 956-JECFA 71 | FAS 62-JECFA 71
Source: WHO/JECFA
EU Food Improvement
Food additives
Source: EU Food Improvement Agents

Function Categories & List Membership

Cosmetic/Chemical Function Categories
Biocide Processing aids not otherwise specified pH regulating agent
Regulatory List Membership (2)
EPA Safer Chemical Ingredients List (SCIL) FDA Indirect Food Contact Additives

Editorial summary

Preliminary editorial summary for Sodium Bisulfate — not a computed safety verdict. See the sourced toxicological data above.

Regulatory Flags

epa_safer_alternative

Known Synonyms

Caswell No. 742 EINECS 231-665-7 EPA Pesticide Chemical Code 073201 NSC 71192 Sodium bisulfate, fused Sodium bisulfate, solid(DOT) Sodium hydrogen sulfate, solid Sodium pyrosulfate Sodium sulfate, NaHSO4 UNII-BU8V88OWIQ

Chemical Function

pH regulating agent Processing aids not otherwise specified Biocide

Regulatory Lists

active_ingredient; Pesticides active_ingredient; Pesticides active_ingredient; Pesticides active_ingredient; Pesticides active_ingredient; Pesticides active_ingredient; Pesticides active_ingredient; Pesticides active_ingredient; Pesticides active_ingredient; Pesticides active_ingredient; Pesticides active_ingredient; Pesticides active_ingredient; Pesticides active_ingredient; Pesticides active_ingredient; Pesticides active_ingredient; Pesticides active_ingredient; Pesticides active_ingredient; Pesticides active_ingredient; Pesticides

Australian Status

AICIS status: listed

Cross-Vertical Safety Context

Same-CAS public records found in pharmaceutical and food safety data.

SOURCE ChEMBL / DrugCentral / FAERS DB_PHARMA CAS match

Pharmaceutical Data

Same-CAS rows from the pharmaceutical spoke database.

ChEMBL ID
CHEMBL1200488
View full pharmaceutical profile →
SOURCE EFSA / FDA GRAS food_additives + fda_gras_enriched

Food Safety Data

Same-CAS food additive or FDA GRAS records from the core public database.

Food Name
Sodium bisulfate
E Number
E514ii
FDA GRAS
FDA has no questions
GRN
3
Food Category
flavor_enhancer

Use in cake mixes as a pH control agent and a leavening agent at a level of 0.1 to 1.0 percent by weight; use in foods in general as a pH control agent and processing aid at levels not to exceed good manufacturing practices

View full food safety profile →

Frequently Asked Questions

Is Sodium Bisulfate safe in cosmetics?

Sodium Bisulfate has a safety rating of "MODERATE" in our database. EU status: restricted. US status: permitted.

Is Sodium Bisulfate allowed in the EU?

Sodium Bisulfate EU regulatory status: restricted. Maximum allowed concentration: 0.2%. This is based on EU Regulation 1223/2009 and its amendments.

What does Sodium Bisulfate do in cosmetics?

Sodium Bisulfate functions as: pH adjuster; buffering agent. It is classified as a cosmetic ingredient in our database. CAS number: 7681-38-1.

Is Sodium Bisulfate used outside cosmetics?

Sodium Bisulfate also appears in industrial chemical safety, pharmaceutical, and food safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.

Does Sodium Bisulfate have different safety status in cosmetics vs industrial chemicals?

Sodium Bisulfate is classified GHS Danger (H318, H319) in the chemicals database but is restricted in EU cosmetics at max 0.2%.

Compliance Tools

Check Sodium Bisulfate compliance across multiple jurisdictions:

Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions

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