Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
5 study endpoints found for Sodium Bisulfate. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| LOAEL | 2 other | dermal | code:3484 | dermal | REACH |
| NOEL | 1000 mg/kg bw/day | oral | rat | oral | REACH |
| NOAEL | ca.2000 mg/kg bw/day | oral | rat | oral | REACH |
| LOAEL | ca.3860 ppm | oral | code:3544 | oral | REACH |
| LOAEL | ca.0.8 other | oral | code:3544 | oral | REACH |
Expert Verdict
Strongly acidic (pH ~1 in solution) — handle with care in manufacturing; sulfite sensitivity in asthmatics is a documented concern; ensure final product pH is within safe range (typically 4.5–8.5 for skin products); labeling may require sulfite declaration depending on jurisdiction
Regulatory Flags
Frequently Asked Questions
Is Sodium Bisulfate safe in cosmetics?
Strongly acidic (pH ~1 in solution) — handle with care in manufacturing; sulfite sensitivity in asthmatics is a documented concern; ensure final product pH is within safe range (typically 4.5–8.5 for skin products); labeling may require sulfite declaration depending on jurisdiction The EU classifies Sodium Bisulfate as "restricted". Safety rating: MODERATE. 5 toxicological study endpoint(s) are available in our database.
Is Sodium Bisulfate allowed in the EU?
Sodium Bisulfate EU regulatory status: restricted. Maximum allowed concentration: 0.2%. This is based on EU Regulation 1223/2009 and its amendments.
What does Sodium Bisulfate do in cosmetics?
Sodium Bisulfate functions as: pH adjuster; buffering agent. It is classified as a cosmetic ingredient in our database. CAS number: 7681-38-1.
What is the Margin of Safety for Sodium Bisulfate?
adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Sodium Bisulfate?
The NOAEL (No Observed Adverse Effect Level) for Sodium Bisulfate is 2 other based on a dermal study via dermal route in code:3484. A total of 5 study endpoints are available. Source: REACH.
Compliance Tools
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Related Ingredients
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