Sodium Carboxymethyl Cellulose
INCI: SODIUM CARBOXYMETHYL CELLULOSE
Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
10 study endpoints found for Sodium Carboxymethyl Cellulose. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 1500 mg/kg bw/day | oral | mouse | Carcinogenicity | COSMOS_DB |
| NOAEL | 50 mg/kg bw/day | oral | mouse | Carcinogenicity | COSMOS_DB |
| NOAEL | 500 mg/kg bw/day | oral | rat | Carcinogenicity | COSMOS_DB |
| NOAEL | 5 mg/kg bw/day | oral | rat | Carcinogenicity | COSMOS_DB |
| NOAEL | 1600 mg/kg bw/day | oral | mouse | Developmental | COSMOS_DB |
| NOAEL | 1600 mg/kg bw/day | oral | rat | Developmental | COSMOS_DB |
| NOAEL | 200 mg/kg bw/day | oral | rat | Reproductive | COSMOS_DB |
| NOAEL | 500 mg/kg bw/day | oral | rat | Short Term Toxicity | COSMOS_DB |
| NOAEL | 2500 mg/kg bw/day | oral | rat | Subchronic | COSMOS_DB |
| NOAEL | 10000 mg/kg bw/day | oral | rat | Short Term Toxicity | COSMOS_DB |
Expert Verdict
Good safety profile with no skin penetration; generally considered safe for cosmetic use.
Regulatory Flags
Frequently Asked Questions
Is Sodium Carboxymethyl Cellulose safe in cosmetics?
Good safety profile with no skin penetration; generally considered safe for cosmetic use. The EU classifies Sodium Carboxymethyl Cellulose as "permitted". Safety rating: GOOD. 10 toxicological study endpoint(s) are available in our database.
Is Sodium Carboxymethyl Cellulose allowed in the EU?
Sodium Carboxymethyl Cellulose EU regulatory status: permitted. Maximum allowed concentration: 20%. This is based on EU Regulation 1223/2009 and its amendments.
What does Sodium Carboxymethyl Cellulose do in cosmetics?
Sodium Carboxymethyl Cellulose functions as: Emulsifier. It is classified as a Cosmetic Ingredient in our database. CAS number: 9004-32-4.
What is the Margin of Safety for Sodium Carboxymethyl Cellulose?
adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Sodium Carboxymethyl Cellulose?
The NOAEL (No Observed Adverse Effect Level) for Sodium Carboxymethyl Cellulose is 1500 mg/kg bw/day based on a Carcinogenicity study via oral route in mouse. A total of 10 study endpoints are available. Source: COSMOS_DB.
Compliance Tools
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Related Ingredients
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