Good Cosmetic Ingredient NOAEL Data

Sodium Caseinate

INCI: SODIUM CASEINATE

CAS Number
9005-46-3
Function
Antistatic, hair conditioning, skin conditioning
Safety Rating
GOOD

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes Permitted; also GRAS as a food additive (21 CFR 182.1748), which supports safety profile

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
negligible
Sensitization
moderate

Calculate MoS for your specific formulation with the MoS Calculator.

Toxicological Studies

3 study endpoints found for Sodium Caseinate. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint Value Route Species Study Type Source
NOAEL 190 mg/kg bw/day oral rabbit Developmental COSMOS_DB
NOAEL 1600 mg/kg bw/day oral mouse Developmental COSMOS_DB
dose_tested 1600 mg/kg bw/day oral mouse Developmental COSMOS_DB

Expert Verdict

Milk allergen โ€” must be considered for labeling; animal origin (dairy); not suitable for vegan claims; potential cross-reactivity in milk-allergic individuals

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Concern Level: Moderate

Regulatory Flags

potential-allergen fda_food_additive jecfa_safe

Frequently Asked Questions

Is Sodium Caseinate safe in cosmetics?

Milk allergen โ€” must be considered for labeling; animal origin (dairy); not suitable for vegan claims; potential cross-reactivity in milk-allergic individuals The EU classifies Sodium Caseinate as "permitted". Safety rating: GOOD. 3 toxicological study endpoint(s) are available in our database.

Is Sodium Caseinate allowed in the EU?

Sodium Caseinate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Sodium Caseinate do in cosmetics?

Sodium Caseinate functions as: Antistatic, hair conditioning, skin conditioning. It is classified as a cosmetic ingredient in our database. CAS number: 9005-46-3.

What is the Margin of Safety for Sodium Caseinate?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

What is the NOAEL for Sodium Caseinate?

The NOAEL (No Observed Adverse Effect Level) for Sodium Caseinate is 190 mg/kg bw/day based on a Developmental study via oral route in rabbit. A total of 3 study endpoints are available. Source: COSMOS_DB.

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