Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
3 study endpoints found for Sodium Cocoyl Isethionate. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 200 mg/kg bw/day | oral | rat | oral | REACH |
| NOAEL | >=2070 mg/kg bw/day | dermal | rat | dermal | REACH |
| NOAEL | >=1000 mg/kg bw/day | oral | rat | oral | REACH |
Expert Verdict
Gold standard surfactant for syndet bars and sensitive skin cleansing. Isethionate ester of coconut fatty acids with significantly lower irritation than SLS. Double-blind trial in 124 rosacea patients showed 42% less stinging, 29% less erythema, and zero TEWL change versus SLS. A 14% SCI / 6% CAPB / 3% glycerin formulation produces 22% TEWL reduction and 31% hydration increase within 10 days. First-choice surfactant for rosacea, atopic, and barrier-compromised skin.
Regulatory Flags
Frequently Asked Questions
Is Sodium Cocoyl Isethionate safe in cosmetics?
Gold standard surfactant for syndet bars and sensitive skin cleansing. Isethionate ester of coconut fatty acids with significantly lower irritation than SLS. Double-blind trial in 124 rosacea patients showed 42% less stinging, 29% less erythema, and zero TEWL change versus SLS. A 14% SCI / 6% CAPB / 3% glycerin formulation produces 22% TEWL reduction and 31% hydration increase within 10 days. First-choice surfactant for rosacea, atopic, and barrier-compromised skin. The EU classifies Sodium Cocoyl Isethionate as "permitted". Safety rating: GOOD. 3 toxicological study endpoint(s) are available in our database.
Is Sodium Cocoyl Isethionate allowed in the EU?
Sodium Cocoyl Isethionate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Sodium Cocoyl Isethionate do in cosmetics?
Sodium Cocoyl Isethionate functions as: Surfactant; primary cleanser; syndet bar base. It is classified as a Surfactant in our database. CAS number: 61789-32-0.
What is the Margin of Safety for Sodium Cocoyl Isethionate?
adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Sodium Cocoyl Isethionate?
The NOAEL (No Observed Adverse Effect Level) for Sodium Cocoyl Isethionate is 200 mg/kg bw/day based on a oral study via oral route in rat. A total of 3 study endpoints are available. Source: REACH.
Compliance Tools
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Related Ingredients
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