Is Sodium Cocoyl Isethionate safe in cosmetics?
Sodium Cocoyl Isethionate has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted.
Good
Surfactant
Sodium Cocoyl Isethionate
Also known as: Fatty acids, coco, 2-sulfoethyl esters, sodium salts, Sodium coco fatty acid isethionate, Coconut fatty acid, 2-sulfoethyl ester, sodium salt, EINECS 263-052-5, Sodium cocoyl isothionate (+1 more)
INCI: SODIUM COCOYL ISETHIONATE
Sodium Cocoyl Isethionate (CAS 61789-32-0) is a cosmetic surfactant functioning as Surfactant; primary cleanser; syndet bar base. NOAEL 200 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety data.
View industrial chemical safety profile for CAS 61789-32-0 →
Auto-generated CPSR Part A draft with source citations
Function
Surfactant; primary cleanser; syndet bar base
Safety Rating
GOOD
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
CIR assessment confirms SCI is irritating but significantly less so than SLS. Used at 5–50% in syndet (synthetic detergent) bars. Core ingredient of Dove Original Beauty Bar. Clinical trial (n=124, mild-to-moderate rosacea) demonstrates 42% stinging reduction and 29% erythema decrease vs SLS.
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Sodium Cocoyl Isethionate.
Calculate MoS for your specific formulation with the MoS Calculator.
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for Sodium Cocoyl Isethionate across SCCS product categories, with measured dermal absorption where available.
EPA ToxValDB — Toxicity Values
10 toxicity values from EPA ToxValDB (aggregated from CCTE, HPV, ToxRefDB, IRIS, and other regulatory dossiers).
| Endpoint | Value | Species | Route | Duration | Source |
|---|---|---|---|---|---|
| LD50 | >2000 mg/kg | Rat | oral | - | ECHA IUCLID |
| NOAEL | >=2070 mg/kg-day | Rat | dermal | acute | ECHA IUCLID |
| LD50 | >2000 mg/kg | Rat | dermal | short-term | ECHA IUCLID |
| LOAEL | >1 % diet | Rat | oral | short-term | HPVIS |
| NOAEL | =1 % diet | Rat | oral | short-term | HPVIS |
| NOAEL | =1 % diet | Rat | oral | short-term | HPVIS |
| LOAEL | >36 % diet | Rat | dermal | short-term | HPVIS |
| LOAEL | =40 % diet | Rat | dermal | short-term | HPVIS |
| NOAEL | =20 % diet | Rat | dermal | short-term | HPVIS |
| NOAEL | =36 % diet | Rat | dermal | short-term | HPVIS |
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
1,000 - 10,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Typical Use Concentrations
Reported concentration ranges per product category from SCCS/CIR/industry sources.
| Product Category | Typical Range | Max Reported | Source |
|---|---|---|---|
| Bar Soap | 30–70 | 80 | CIR/VCRP |
| Body Wash | 3–8 | 15 | CIR/VCRP |
Additional Ingredient Properties
10 property records from structured ingredient metadata.
acne
{"cas_number": "61789-32-0", "anti_acne_mechanism": "antibacterial", "comedogenicity_rating_0_to_5": "0-1", "acne_type_efficacy": "inflammatory", "sebum_reduction_pct_clinical": "0-5", "prescription_required_usa": "No", "otc_drug_monograph_category": "No", "max_otc_concentration_pct": "No limit", "japan_quasi_drug_anti_acne": "No", "korea_functional_cosmetic_acne": "No", "eu_cosmetic_restriction_a…
baby_pediatric
{"cas_number": "61789-32-0", "ingredient_class": "cleanser_baby", "pediatric_safety_rating": "excellent", "minimum_age_months": "0", "neonatal_safe": "yes", "premature_infant_safe": "yes", "skin_barrier_maturity_consideration": "Ultra-mild, sulfate-free, compatible with baby skin pH", "transepidermal_absorption_risk_pediatric": "low", "dose_per_kg_body_weight_concern": "Safe at <20%", "skin_surfac…
comedogenicity_detail
{"comedogenicity_rating": "0", "irritancy_rating": "1", "skin_type_suitability": "all,oily,combination,normal,acne-prone", "acne_safe": "yes", "source": "Mild synthetic"}
concentration
{"min_concentration_pct": "20.0", "max_concentration_pct": "60.0", "typical_concentration_pct": "40.0", "product_type": "Cleansing Bar", "function_at_concentration": "Mild surfactant", "source": "CIR Safety Assessment"}
cost_pricing
{"cost_tier": "mid-range", "estimated_cost_per_kg_usd_low": "15", "estimated_cost_per_kg_usd_high": "28", "natural_premium_markup_pct": "30", "organic_certified_premium_pct": "60", "supply_chain_volatility": "medium", "primary_source_region": "Malaysia/Europe", "synthetic_vs_natural_cost_ratio": "2.0", "bulk_discount_threshold_kg": "100", "seasonal_price_variation": "low", "commodity_or_specialty"…
emulsifier
{"cas_number": "61789-32-0", "ingredient_class": "O/W_emulsifier,PEG_free_emulsifier", "chemical_type": "amino_acid_based", "HLB_value": "16.0", "HLB_required_for_oil_phase": "14-18", "emulsion_type_primary": "O/W", "droplet_size_typical_um": "0.5-2", "critical_micelle_concentration_pct": "0.01-0.05", "surface_tension_reduction_mN_m": "36", "interfacial_tension_reduction": "40", "foam_formation": …
emulsion_hlb
{"hlb_required_as_emulsifier": "yes", "emulsifier_type": "o_w", "critical_packing_parameter": "0.24-0.34", "emulsion_stabilization_mechanism": "electrostatic_steric", "co_emulsifier_pairs": "cocamidopropyl_betaine", "optimal_oil_phase_pct": "5-18", "optimal_water_phase_pct": "82-95", "electrolyte_tolerance": "low", "pH_emulsion_stability_range": "5.0-9.5", "viscosity_building_contribution": "low-m…
hair_care
{"hair_function": "cleansing", "hair_type_suitability": "all", "curl_pattern_suitability": "all", "porosity_suitability": "all", "protein_sensitivity": "neutral", "moisture_protein_balance": "yes", "cg_method_approved": "not-a-silicone", "silicone_type": "mild", "sulfate_type": "no", "drying_alcohol": "no", "fatty_alcohol": "no", "heat_protectant": "yes", "color_safe": "neutral", "keratin_bond": "…
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Cleaning agent
Softener and conditioner
Surfactant (surface active agent)
Regulatory List Membership (1)
EPA Safer Chemical Ingredients List (SCIL)
Expert Verdict
Expert safety assessment and concern-level summary for Sodium Cocoyl Isethionate.
Regulatory Flags
mild-anionic
syndet
barrier-compatible
clinical-data
rosacea-safe
sulfate-free
epa_safer_alternative
Known Synonyms
Fatty acids, coco, 2-sulfoethyl esters, sodium salts
Sodium coco fatty acid isethionate
Coconut fatty acid, 2-sulfoethyl ester, sodium salt
EINECS 263-052-5
Sodium cocoyl isothionate
UNII-518XTE8493
Chemical Function
Surfactant (surface active agent)
Cleaning agent
Softener and conditioner
Regulatory Lists
SCIL (9/2019)
Australian Status
AICIS status: listed
Frequently Asked Questions
Is Sodium Cocoyl Isethionate allowed in the EU?
Sodium Cocoyl Isethionate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Sodium Cocoyl Isethionate do in cosmetics?
Sodium Cocoyl Isethionate functions as: Surfactant; primary cleanser; syndet bar base. It is classified as a Surfactant in our database. CAS number: 61789-32-0.
Is Sodium Cocoyl Isethionate used outside cosmetics?
Sodium Cocoyl Isethionate also appears in industrial chemical safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Sodium Cocoyl Isethionate compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
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Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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