Is Sodium Gluconate safe in cosmetics?
Sodium Gluconate has a safety rating of "EXCELLENT" in our database. EU status: permitted. US status: permitted.
Sodium Gluconate
Also known as: D-Gluconic acid, monosodium salt, EINECS 208-407-7, Gluconato di sodio, UNII-R6Q3791S76, Monosodium D-gluconate (+1 more)
INCI: SODIUM GLUCONATE
Sodium Gluconate (CAS 527-07-1) is a cosmetic cosmetic ingredient functioning as Chelating agent; metal ion sequestrant; preservative booster. EU Regulation 1223/2009 status: permitted, max 0.10–0.50%. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in pharmaceutical and food safety data.
Function
Chelating agent; metal ion sequestrant; preservative booster
Editorial assessment
EXCELLENT
Preliminary editorial note — not a computed safety verdict.
Regulatory Status
EU EU Status
permitted
EU Max Conc.
0.10–0.50%
US US Status
permitted
US Notes
Permitted without restriction. GRAS as food additive. Produced by fermentation; non-synthetic origin broadly accepted. No adverse CIR findings.
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Sodium Gluconate.
Calculate MoS for your specific formulation with the MoS Calculator.
GHS Hazard Classification
Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.
Hazard Statements
No hazard classification according to GHS criteria
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Chelating agent
Cleaning agent
Dye
Flavouring and nutrient
Processing aids not otherwise specified
Softener and conditioner
pH regulating agent
Regulatory List Membership (4)
EU Regulated in Personal Care
EU Restricted for Children (Cosmetics)
EPA Safer Chemical Ingredients List (SCIL)
FDA Substances Added to Food (EAFUS)
Editorial summary
Preliminary editorial summary for Sodium Gluconate — not a computed safety verdict. See the sourced toxicological data above.
Regulatory Flags
cosmos-approved
ecocert-approved
readily-biodegradable
fermentation-derived
natural-derived
edta-alternative
preservative-booster
eu_children_restricted
epa_safer_alternative
fda_food_additive
jecfa_safe
Known Synonyms
D-Gluconic acid, monosodium salt
EINECS 208-407-7
Gluconato di sodio
UNII-R6Q3791S76
Monosodium D-gluconate
sodium (2R,3S,4R,5R)-2,3,4,5,6-pentahydroxyhexanoate
Chemical Function
Chelating agent
Softener and conditioner
Regulatory Lists
inert_ingredient; Pesticides
inert_ingredient; non_food_use; Pesticides
Europe; supplements
Europe; food_additive; supplements
children; Europe; Personal care
children; Europe; Personal care
animal_products
animal_products
Europe; Personal care
Europe; Personal care
Europe; Personal care
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
SCIL (9/2019)
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical and food safety data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL1200919
Adverse Event Associations
2
SOURCE
EFSA / FDA GRAS
food_additives
Food Safety Data
Same-CAS food additive or FDA GRAS records from the core public database.
Food Name
Sodium gluconate
E Number
E576
ADI
NOT SPECIFIED mg/kg bw
Food Category
preservative
Frequently Asked Questions
Is Sodium Gluconate allowed in the EU?
Sodium Gluconate EU regulatory status: permitted. Maximum allowed concentration: 0.10–0.50%. This is based on EU Regulation 1223/2009 and its amendments.
What does Sodium Gluconate do in cosmetics?
Sodium Gluconate functions as: Chelating agent; metal ion sequestrant; preservative booster. It is classified as a cosmetic ingredient in our database. CAS number: 527-07-1.
Is Sodium Gluconate used outside cosmetics?
Sodium Gluconate also appears in pharmaceutical and food safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Sodium Gluconate compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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