Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
10 study endpoints found for Copper Gluconate. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 1140 mg/kg bw/day | oral | rat | Chronic | COSMOS_DB |
| NOAEL | 180 mg/kg bw/day | oral | dog | Chronic | COSMOS_DB |
| NOAEL | 30 mg/kg bw/day | oral | mouse | Developmental | COSMOS_DB |
| NOAEL | 30 mg/kg bw/day | oral | rat | Developmental | COSMOS_DB |
| NOAEL | 30 mg/kg bw/day | oral | rat | Reproductive | COSMOS_DB |
| NOAEL | 30 mg/kg bw/day | oral | rat | Reproductive | COSMOS_DB |
| dose_tested | 180 mg/kg bw/day | oral | dog | Chronic | COSMOS_DB |
| dose_tested | 30 mg/kg bw/day | oral | mouse | Developmental | COSMOS_DB |
| dose_tested | 30 mg/kg bw/day | oral | rat | Developmental | COSMOS_DB |
| dose_tested | 30 mg/kg bw/day | oral | rat | Reproductive | COSMOS_DB |
Expert Verdict
Copper Gluconate is generally considered safe for use as a skin-conditioning agent with established margin of safety.
Regulatory Flags
Frequently Asked Questions
Is Copper Gluconate safe in cosmetics?
Copper Gluconate is generally considered safe for use as a skin-conditioning agent with established margin of safety. The EU classifies Copper Gluconate as "permitted". Safety rating: GOOD. 10 toxicological study endpoint(s) are available in our database.
Is Copper Gluconate allowed in the EU?
Copper Gluconate EU regulatory status: permitted. Maximum allowed concentration: 1%. This is based on EU Regulation 1223/2009 and its amendments.
What does Copper Gluconate do in cosmetics?
Copper Gluconate functions as: skin-conditioning agent. It is classified as a Cosmetic Ingredient in our database. CAS number: 527-09-3.
What is the Margin of Safety for Copper Gluconate?
adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Copper Gluconate?
The NOAEL (No Observed Adverse Effect Level) for Copper Gluconate is 1140 mg/kg bw/day based on a Chronic study via oral route in rat. A total of 10 study endpoints are available. Source: COSMOS_DB.
Compliance Tools
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