Is Copper Gluconate safe in cosmetics?
Copper Gluconate has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted.
GOOD
Cosmetic Ingredient
Copper Gluconate
Also known as: Copper, bis(D-gluconato-κO1,κO2)-, Copper, bis(D-gluconato-O1,O2)-, Bis(D-gluconato-κO1,κO2)copper, D-Gluconic acid, copper complex, Cupric gluconate (+15 more)
INCI: COPPER GLUCONATE
Copper Gluconate (CAS 527-09-3) is a cosmetic cosmetic ingredient functioning as skin-conditioning agent. NOAEL 30 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: permitted, max 1%. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety, pharmaceutical, and food safety data.
Function
skin-conditioning agent
Editorial assessment
GOOD
Preliminary editorial note — not a computed safety verdict.
Regulatory Status
EU EU Status
permitted
EU Max Conc.
1%
US US Status
permitted
US Notes
CIR Panel concluded it is safe in present practices of use and concentration (Final Report, March 2025)
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Copper Gluconate.
Calculate MoS for your specific formulation with the MoS Calculator.
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for Copper Gluconate across SCCS product categories, with measured dermal absorption where available.
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
100 - 1,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Flavouring and nutrient
Humectant
No specific technical function
Pharmaceutical
Softener and conditioner
Regulatory List Membership (1)
FDA Substances Added to Food (EAFUS)
Editorial summary
Preliminary editorial summary for Copper Gluconate — not a computed safety verdict. See the sourced toxicological data above.
Regulatory Flags
fda_food_additive
Known Synonyms
Copper, bis(D-gluconato-κO1,κO2)-
Copper, bis(D-gluconato-O1,O2)-
Bis(D-gluconato-κO1,κO2)copper
D-Gluconic acid, copper complex
Cupric gluconate
D-Gluconic acid, copper(2+) salt
Helshas Cu
Labicuper
Di-D-gluconate de cuivre
copper di-D-gluconate
Kupferdi-D-gluconat
di-D-gluconato de cobre
Copper, bis(D-gluconato)-
Cobre, bis(D-gluconato-κO1,κO2)-
Gluconic acid, copper(2+) salt (2:1), D-
Copper(II) gluconate
D-Gluconic acid, copper(2+) salt (2:1)
Copper(2+) di(D-gluconate)
Copper, bis(D-gluconato-.kappa.O1,.kappa.O2)-
Bis(D-gluconato-O1,O2)copper
Chemical Function
Humectant
Softener and conditioner
No specific technical function
Pharmaceutical
Flavouring and nutrient
Regulatory Lists
active_ingredient; animal_products; Europe; pharmaceutical; residue
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
Canada; pharmaceutical
Canada; pharmaceutical
inert_ingredient; Pesticides
inert_ingredient; non_food_use; Pesticides
Europe; supplements
Europe; food_additive; supplements
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical and food safety data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA count match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Adverse Event Associations
134
SOURCE
EFSA / FDA GRAS
food_additives
Food Safety Data
Same-CAS food additive or FDA GRAS records from the core public database.
Food Name
Copper gluconate (color)
Food Category
colorant
Frequently Asked Questions
Is Copper Gluconate allowed in the EU?
Copper Gluconate EU regulatory status: permitted. Maximum allowed concentration: 1%. This is based on EU Regulation 1223/2009 and its amendments.
What does Copper Gluconate do in cosmetics?
Copper Gluconate functions as: skin-conditioning agent. It is classified as a cosmetic ingredient in our database. CAS number: 527-09-3.
Is Copper Gluconate used outside cosmetics?
Copper Gluconate also appears in industrial chemical safety, pharmaceutical, and food safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Copper Gluconate compliance across multiple jurisdictions:
Ingredient Decoder
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Substance Compliance
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MoS Calculator
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Heavy Metal Limits
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