TBHQ
Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Toxicological Studies
10 study endpoints found for TBHQ. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 125 mg/kg bw/day | oral | dog | Chronic | COSMOS_DB |
| NOAEL | 250 mg/kg bw/day | oral | rat | Chronic | COSMOS_DB |
| NOAEL | 250 mg/kg bw/day | oral | rat | Carcinogenicity | COSMOS_DB |
| NOAEL | 250 mg/kg bw/day | oral | rat | Multigeneration Reproductive | COSMOS_DB |
| NOAEL | 250 mg/kg bw/day | oral | rat | Reproductive-developmental | COSMOS_DB |
| NOAEL | 250 mg/kg bw/day | oral | rat | Subchronic | COSMOS_DB |
| NOAEL | 277 mg/kg bw/day | oral | rat | Reproductive | COSMOS_DB |
| NOAEL | 326 mg/kg bw/day | oral | rat | Developmental | COSMOS_DB |
| NOAEL | 1000 mg/kg bw/day | oral | rat | Chronic | COSMOS_DB |
| NOAEL | 600 mg/kg bw/day | oral | hamster | Subchronic | COSMOS_DB |
Expert Verdict
TBHQ is listed in the EU CosIng database with functions: Antioxidant, Fragrance, Perfuming It is permitted in the EU without specific restrictions.
Regulatory Flags
Frequently Asked Questions
Is TBHQ safe in cosmetics?
TBHQ is listed in the EU CosIng database with functions: Antioxidant, Fragrance, Perfuming It is permitted in the EU without specific restrictions. The EU classifies TBHQ as "Permitted". Safety rating: GOOD. 10 toxicological study endpoint(s) are available in our database.
Is TBHQ allowed in the EU?
TBHQ EU regulatory status: Permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does TBHQ do in cosmetics?
TBHQ functions as: Antioxidant, Fragrance, Perfuming. It is classified as a cosmetic ingredient in our database. CAS number: 1948-33-0.
What is the NOAEL for TBHQ?
The NOAEL (No Observed Adverse Effect Level) for TBHQ is 125 mg/kg bw/day based on a Chronic study via oral route in dog. A total of 10 study endpoints are available. Source: COSMOS_DB.
Compliance Tools
Check TBHQ compliance across multiple jurisdictions:
Related Ingredients
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