Is Tetrapotassium Pyrophosphate safe in cosmetics?
Tetrapotassium Pyrophosphate has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted.
Tetrapotassium Pyrophosphate
Also known as: Potassium diphosphate (K4P2O7), Diphosphoric acid, tetrapotassium salt, UN 3287, Potassium phosphate (K4P2O7), EINECS 230-785-7 (+2 more)
INCI: TETRAPOTASSIUM PYROPHOSPHATE
Tetrapotassium Pyrophosphate (CAS 7320-34-5) is a cosmetic cosmetic ingredient functioning as Tartar control agent by chelating calcium and magnesium ions from saliva,. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and food safety data.
Function
Tartar control agent by chelating calcium and magnesium ions from saliva, preventing their deposition. Also functions as a corrosion inhibitor and pH adjuster.
Editorial assessment
GOOD
Preliminary editorial note — not a computed safety verdict.
Chemistry & Identifiers
IUPAC Name
tetrapotassium;phosphonato phosphate
InChIKey
RYCLIXPGLDDLTM-UHFFFAOYSA-J
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
CIR safety assessment lists it as a corrosion inhibitor and pH adjuster.
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Tetrapotassium Pyrophosphate.
Calculate MoS for your specific formulation with the MoS Calculator.
GHS Hazard Classification
Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.
Short-term Exposure Effects
The substance is corrosive to the eyes, skin and respiratory tract. Corrosive on ingestion. Inhalation of the aerosol may cause lung oedema. See Notes.
Routes of Exposure
The substance can be absorbed into the body by inhalation of dust.
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
10,000 - 100,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (1)
ICSC Safety Card
0983
Source: WHO/JECFA
Regulatory (2)
JECFA Evaluation
TETRAPOTASSIUM DIPHOSPHATE | 1982 | Group MTDI for phosphorus from all sources, expressed as P | TRS 683-JECFA 26/25 | FAS 17-JECFA 26/151
Source: WHO/JECFA
EU Food Improvement
Food additives
Source: EU Food Improvement Agents
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Chelating agent
Corrosion inhibitor
Emulsifier
Other
Oxidizing agent
Surfactant (surface active agent)
Thickening agent
pH regulating agent
Regulatory List Membership (2)
EPA Safer Chemical Ingredients List (SCIL)
FDA Substances Added to Food (EAFUS)
Editorial summary
Preliminary editorial summary for Tetrapotassium Pyrophosphate — not a computed safety verdict. See the sourced toxicological data above.
Regulatory Flags
epa_safer_alternative
fda_food_additive
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to Tetrapotassium Pyrophosphate by CAS number or substance name.
Studies
3
Lowest NOAEL
500 mg/kg bw/day
Highest NOAEL
500 mg/kg bw/day
ECHA
Known Synonyms
Potassium diphosphate (K4P2O7)
Diphosphoric acid, tetrapotassium salt
UN 3287
Potassium phosphate (K4P2O7)
EINECS 230-785-7
Tetrapotassium diphosphorate
UNII-B9W4019H5G
Chemical Function
Chelating agent
pH regulating agent
Corrosion inhibitor
Surfactant (surface active agent)
Regulatory Lists
Canada; consumer_product; Substances in Products - Canada (4/2014)
inert_ingredient; non_food_use; Pesticides
animal_products
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in food safety data.
SOURCE
EFSA / FDA GRAS
food_additives
Food Safety Data
Same-CAS food additive or FDA GRAS records from the core public database.
Food Name
Tetrapotassium diphosphate
E Number
E450v
ADI
40 mg/kg bw
Food Category
emulsifier
Frequently Asked Questions
Is Tetrapotassium Pyrophosphate allowed in the EU?
Tetrapotassium Pyrophosphate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Tetrapotassium Pyrophosphate do in cosmetics?
Tetrapotassium Pyrophosphate functions as: Tartar control agent by chelating calcium and magnesium ions from saliva, preventing their deposition. Also functions as a corrosion inhibitor and pH adjuster.. It is classified as a cosmetic ingredient in our database. CAS number: 7320-34-5.
Is Tetrapotassium Pyrophosphate used outside cosmetics?
Tetrapotassium Pyrophosphate also appears in industrial chemical safety and food safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
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Substance Compliance
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MoS Calculator
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Heavy Metal Limits
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