Excellent Cosmetic Ingredient NOAEL Data

Theobroma Cacao Extract

INCI: THEOBROMA CACAO (COCOA) EXTRACT

CAS Number
84649-99-0
Function
Antioxidant, Skin Conditioning
Safety Rating
EXCELLENT

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes Not restricted; widely used in cosmetics; CIR reviewed cocoa-derived ingredients as safe

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
moderate
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Toxicological Studies

2 study endpoints found for Theobroma Cacao Extract. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint Value Route Species Study Type Source
NOAEL 4280 mg/kg bw/day oral rat Short Term Toxicity COSMOS_DB
NOAEL 2140 mg/kg bw/day oral rat Short Term Toxicity COSMOS_DB

Expert Verdict

Check for theobromine/caffeine content depending on extraction method. Ensure extraction solvent residues meet limits. Rich in flavonoids โ€” potential interactions with certain actives.

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Concern Level: None

Regulatory Flags

plant-extract fda_food_additive

Frequently Asked Questions

Is Theobroma Cacao Extract safe in cosmetics?

Check for theobromine/caffeine content depending on extraction method. Ensure extraction solvent residues meet limits. Rich in flavonoids โ€” potential interactions with certain actives. The EU classifies Theobroma Cacao Extract as "permitted". Safety rating: EXCELLENT. 2 toxicological study endpoint(s) are available in our database.

Is Theobroma Cacao Extract allowed in the EU?

Theobroma Cacao Extract EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Theobroma Cacao Extract do in cosmetics?

Theobroma Cacao Extract functions as: Antioxidant, Skin Conditioning. It is classified as a cosmetic ingredient in our database. CAS number: 84649-99-0.

What is the Margin of Safety for Theobroma Cacao Extract?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

What is the NOAEL for Theobroma Cacao Extract?

The NOAEL (No Observed Adverse Effect Level) for Theobroma Cacao Extract is 4280 mg/kg bw/day based on a Short Term Toxicity study via oral route in rat. A total of 2 study endpoints are available. Source: COSMOS_DB.

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