Is Thioglycerin safe in cosmetics?
Thioglycerin has a safety rating of "MODERATE" in our database. EU status: restricted. US status: restricted.
Moderate
Cosmetic Ingredient
Thioglycerin
Also known as: 3-01-00-02339, BRN 1732046, EINECS 202-495-0, Glycerol, 1-thio-, 3-Mercapto-1,2-propanediole (+5 more)
INCI: THIOGLYCERIN
Thioglycerin (CAS 96-27-5) is a cosmetic cosmetic ingredient functioning as Depilatory, Hair Waving/Straightening, Keratolytic, Reducing Agent. NOAEL 20 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: restricted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 96-27-5 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
Thioglycerin is classified GHS Danger (H302, H311, H315, H317, H319, H331, H335) in the chemicals database but is restricted in EU cosmetics.
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
Depilatory, Hair Waving/Straightening, Keratolytic, Reducing Agent
Safety Rating
MODERATE
Chemistry & Identifiers
IUPAC Name
3-sulfanylpropane-1,2-diol
InChIKey
PJUIMOJAAPLTRJ-UHFFFAOYSA-N
Regulatory Status
EU EU Status
restricted
US US Status
restricted
US Notes
Permitted; not specifically restricted; subject to general safety requirements
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Thioglycerin.
Calculate MoS for your specific formulation with the MoS Calculator.
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for Thioglycerin across SCCS product categories, with measured dermal absorption where available.
Sensitization AOP Dashboard
Adverse Outcome Pathway data across 5 assays (DPRA, KeratinoSens, hCLAT, LLNA, NESIL) aggregated from public sources.
DPRA Cys %
27.3%
DPRA Lys %
28.4%
KeratinoSens IC50
2000 µM
hCLAT CV75
2860.4 µg/mL
NESIL
31034 µg/cm²
GHS: 1B
Human: positive
Source: DPRA: Hoffmann et al., 2018; KS: Emter et al. 2010 [DOI:10.1016/j.taap.2010.03.009]; hCLAT: No reference provided in NICEATM database; HPPT: [27] Kligman AM (1966): https://doi.org/10.1038/jid.1966.160
HRIPT Human Patch Test Studies
5 human repeat insult patch tests aggregated from dermatological literature.
| Test Type | N | Sensitized | Dose µg/cm² | NESIL µg/cm² | Potency |
|---|---|---|---|---|---|
| HMT | - | 0 | 12413.79 | - | - |
| HMT | - | 0 | 12413.79 | - | - |
| HMT | - | 0 | 31034.48 | - | - |
| HRIPT | - | 0 | 1452.57 | - | - |
| OECD_DA_Human | - | 0 | - | - | 1B (Weak sensitizer) |
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
100 - 1,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Depilatory
Hair waving or straightening
Heat stabilizer
Pharmaceutical
Reducing agent
Expert Verdict
Expert safety assessment and concern-level summary for Thioglycerin.
Known Synonyms
3-01-00-02339
BRN 1732046
EINECS 202-495-0
Glycerol, 1-thio-
3-Mercapto-1,2-propanediole
alpha-Thiolglycerol
UNII-AAO1P0WSXJ
monothioglycerin
monothioglycerol
thioglycerine
Chemical Function
Reducing agent
Depilatory
Hair waving or straightening
Pharmaceutical
Heat stabilizer
Regulatory Lists
active_ingredient; animal_products; Europe; pharmaceutical; residue
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
MONOTHIOGLYCEROL
ChEMBL ID
CHEMBL1398948
Max Phase
-1
Frequently Asked Questions
Is Thioglycerin allowed in the EU?
Thioglycerin EU regulatory status: restricted. This is based on EU Regulation 1223/2009 and its amendments.
What does Thioglycerin do in cosmetics?
Thioglycerin functions as: Depilatory, Hair Waving/Straightening, Keratolytic, Reducing Agent. It is classified as a cosmetic ingredient in our database. CAS number: 96-27-5.
Is Thioglycerin used outside cosmetics?
Thioglycerin also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does Thioglycerin have different safety status in cosmetics vs industrial chemicals?
Thioglycerin is classified GHS Danger (H302, H311, H315, H317, H319, H331, H335) in the chemicals database but is restricted in EU cosmetics.
Compliance Tools
Check Thioglycerin compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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