Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
10 study endpoints found for Thioglycerin. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | >=360 mg/kg bw/day | dermal | code:3543 | dermal | REACH |
| NOAEL | >=180 mg/kg bw/day | dermal | rat | dermal | REACH |
| NOAEL | 50 mg/kg bw/day | oral | rat | oral | REACH |
| LOAEL | 200 mg/kg bw/day | oral | rat | oral | REACH |
| NOEL | 1000 ppm | oral | rat | oral | REACH |
| NOAEL | 3 other | oral | rat | oral | REACH |
| NOAEL | 1000 mg/kg bw/day | oral | rat | oral | REACH |
| LOAEL | 60 mg/kg bw/day | oral | rat | oral | REACH |
| LOAEL | 80 mg/kg bw/day | oral | rat | oral | REACH |
| NOEL | 20 mg/kg bw/day | oral | rat | oral | REACH |
Expert Verdict
Skin/eye irritant at high concentrations; strong thiol odor; must comply with Annex III restrictions including mandatory label warnings
Frequently Asked Questions
Is Thioglycerin safe in cosmetics?
Skin/eye irritant at high concentrations; strong thiol odor; must comply with Annex III restrictions including mandatory label warnings The EU classifies Thioglycerin as "restricted". Safety rating: MODERATE. 10 toxicological study endpoint(s) are available in our database.
Is Thioglycerin allowed in the EU?
Thioglycerin EU regulatory status: restricted. This is based on EU Regulation 1223/2009 and its amendments.
What does Thioglycerin do in cosmetics?
Thioglycerin functions as: Depilatory, Hair Waving/Straightening, Keratolytic, Reducing Agent. It is classified as a cosmetic ingredient in our database. CAS number: 96-27-5.
What is the Margin of Safety for Thioglycerin?
adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Thioglycerin?
The NOAEL (No Observed Adverse Effect Level) for Thioglycerin is >=360 mg/kg bw/day based on a dermal study via dermal route in code:3543. A total of 10 study endpoints are available. Source: REACH.
Compliance Tools
Check Thioglycerin compliance across multiple jurisdictions:
Related Ingredients
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